Suche

zur Hauptseite

Institut für Neurowissenschaften und Medizin

Navigation und Service


JuGEx - download

Erscheinungsdatum
13.06.2017

JuGEx is an integrated framework of the AllenBrain and JuBrain atlas for statistical analysis of differential gene expression in the adult human brain.

Cytoarchitecture linked to gene expression to study multilevel human brain organization

Decoding the chain from genes to cognition requires detailed insights how areas with specific gene activities and microanatomical architectures contribute to brain function and dysfunction. The Allen Human Brain Atlas contains regional gene expression data, while JuBrain Atlas offers three-dimensional cytoarchitectonic maps reflecting interindividual variability. To date, an integrated framework that combines the analytical benefits of both scientific platforms towards a multi-level brain atlas of adult humans was not available. We have therefore developed JuGEx, a new method for integrating tissue transcriptome and cytoarchitectonic segregation.

The JuGEx workflow and the GUIs are based on a script distribution that was coded in Matlab (version R2015b, 64bit).

Funding:
This research was supported by the European Union Seventh Framework program (FP7/2007-2013) Grant 604102 (Human Brain Project) to K.A. and S.C.

Reference:
Sebastian Bludau, Thomas W. Mühleisen, Simon B. Eickhoff, Michael J. Hawrylycz, Sven Cichon, Katrin Amunts. Integration of transcriptomic and cytoarchitectonic data implicates a role for MAOA and TAC1 in the limbic-cortical network. 2018, Brain Structure and Function. https://doi.org/10.1007/s00429-018-1620-6


JuGEx - download (zip, 5 MB)


Servicemenü

Homepage