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Entdeckung des fehlenden Puzzleteils in der Corynebakteriellen Zellwand Biosynthese

Graphic of Discovery of the Missing Link in Corynebacterial Cell Wall BiosynthesisA Corynebacterium glutamicum mutant with reduced levels of the LytR-CpsA-Psr protein LcpA displays significant growth defects and morphological changes accompanied by a reduced amount of arabinogalactan in the cell wall.

The enzyme linking arabinogalactan to peptidoglycan has been a long-standing mystery in the cell wall biogenesis of Corynebacteriales. Baumgart et al. showed that a mutant with reduced levels of the LytR-CpsA-Psr protein LcpA displays significant growth defects and morphological changes accompanied by reduced amounts of arabinogalactan in the cell wall. Furthermore, complementation studies using a conditional mutant strain suggest a crucial function of a so-far-uncharacterized C-terminal domain (LytR_C) that is often at the C terminus of the LCP domain in actinobacterial LCP proteins. Their study provides several pieces of evidence that LcpA catalyzes the ligation of arabinogalactan to peptidoglycan in Corynebacterium glutamicum.


http://jb.asm.org/content/198/22/3045.full.pdf+html


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