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Giorgetti

Dr. Alejandro Giorgetti

Assistant Professor

 

Professional career

2015- Visiting Scientist, IAS-5/INM-9 - Computational Biomedicine, Forschungszentrum Jülich, Germany

2011-2014 Visiting Scientist, GRS, Juelich and the RWTH-Aachen, Germany.

2007- Assistant Professor, University of Verona.

2006-2009 Research fellow at the Bioinformatics Program, CRS4, Pula (CA), Sardegna, Italy.

2004-2007 Postdoctoral research fellow at the Biocomputing Unit, Department of Biochemical Sciences, University of Rome "La Sapienza". Rome, Italy.

1999-2000 Quality Control expert of the SPECT system. Sanatorio Privado del Sur. Bahia Blanca, Argentina.

 

Structural Neuroinformatics

Apply, create and maintain web-accessible databases of experimental and computational data, together with innovative software tools, essential for understanding the structure/function of proteins expressed in the nervous system in its normal function and in neurological disorders. Structural Neuroinformatics compresses data obtained by traditional structural bioinformatics of proteins expressed in the brain, combined with computational biophysics calculations performed on wild-type proteins together with proteins modified in relation to brain functioning/malfunctioning.
a) Receptors involved in chemoperception: Bitter taste receptors and olfactory receptors.
b) Development of multiscale approaches aimed at gaining insights into the structure function of receptors of neurobiological interest: GOMoDo server for modelling and docking of GPCR receptors and the coarse-grained/molecular mechanics (MM/CG) hybrid approach

 

Publications

1. A. Grison, S. Zucchelli, A. Urzì, I. Zamparo, D. Lazarevic, G. Pascarella, P. Roncaglia, A. Giorgetti, P. Garcia-Esparcia, C. Vlachouli, R. Simone, F. Persichetti, A.R.R. Forrest, Y. Hayashizaki, P. Carloni, I. Ferrer, C. Lodovichi, C. Plessy, P. Carninci, S. Gustincich. Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules BMC Genomics , vol. 15 , 2014 , pp. 729-744

2. Piccoli S., Musiani F. and Giorgetti A*. (2014). “Dynamic characterization and substrate binding of cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase, an enzyme used in bioremediation”. Journal of Molecular Modeling. 20(12):2531

3. Astegno, A. Allegrini, Piccoli S., Giorgetti A. and Dominici P. (2014). “Role of Active-Site Residues Tyr55 and Tyr114 in Catalysis and Substrate Specificity of Corynebacterium diphtheriae C-S Lyase.” Proteins, 83(1):78-90

4. Montioli R, Dindo M, Giorgetti A, Piccoli S, Cellini B, Voltattorni CB. A comprehensive picture of the mutations associated with aromatic amino acid decarboxylase deficiency: from molecular mechanisms to therapy implications. Hum Mol Genet. 2014 Oct 15;23(20):5429-40

5. Costantini S, Malerba G, Contreas G, Corradi M, Marin Vargas SP, Giorgetti A, Maffeis C. Genetic and bioinformatics analysis of four novel GCK missense variants detected in Caucasian families with GCK-MODY phenotype. Clin Genet. 2014 Apr 16. doi: 10.1111/cge.12406. [Epub ahead of print]

6. S. Piccoli, M. Andreolli, A. Giorgetti, F. Zordan, Silvia Lampis, G. Vallini, Identification of aldolase and ferredoxin reductase within the dbt operon of Burkholderia fungorum DBT1. Journal Of Basic Microbiology , vol. 54 , n. 5 , 2014 , pp. 464-469.

7. Giorgetti, A. "Membrane Proteins: Insights from computational biology" (2014) Biology and Medicine, 6 (1), art. no. 1000e101.

8. Giorgetti, A. Multi-scale computational biology (2014) Biology and Medicine, 6 (1), art. no. 1000e102.

9. Sandal, M.; Paltrinieri, D.; Carloni, P.; Musiani, F.; Giorgetti, A*. “Structure/Function Relationships of Phospholipases C Beta”. Curr Protein Pept Sci. 2013 Dec;14(8): pp. 650-7.

10. Sandal, M.; Duy, T.P.; Cona, M.; Zung, H.; Carloni, P.; Musiani, F.; Giorgetti, A.* (2013) “GOMoDo: a GPCRs online modeling and docking webserver”. PLOS ONE, vol. 8, p. 1-12.

11. Alessandra Astegno, Alejandro Giorgetti, Alessandra Allegrini, Barbara Cellini and Paola Dominici. (2013) “Characterization of C-S Lyase from C.diphtheriae: a possible target for new antimicrobial drugs”. BioMed Research International. vol. 2013, p. 1-13.

12. Stefano Piccoli, Eda Suku, Marianna Garonzi and Alejandro Giorgetti* (2013). Genome-wide Membrane Protein Structure Prediction. Current Genomics (14), pp: 324 – 329.

13. Alessandro Marchiori, Luciana Capece, Alejandro Giorgetti, Paolo Gasparini, Maik Behrens,Paolo Carloni,Wolfgang Meyerhof, Coarse-Grained/Molecular Mechanics of the TAS2R38 Bitter Taste Receptor: Experimentally-Validated Detailed Structural Prediction of Agonist Binding «PLoS ONE» , vol. 8 , n. 5 , 2013 , pp. 1-12.

14. Bisha I, Laio A, Magistrato A, Giorgetti A and Sgrignani J. (2013). A Candidate Ion-Retaining State in the Inward-Facing Conformation of Sodium/Galactose Symporter: Clues from Atomistic Simulations. J. Chem. Theory Comput., 2013, 9 (2), pp 1240–1246

15. Leguèbe M, Nguyen C, Capece L, Hoang Z, Giorgetti A*, et al. (2012). Hybrid Molecular Mechanics/Coarse-Grained Simulations for Structural Prediction of G-Protein Coupled Receptor/Ligand Complexes. PLoS ONE 7(10): e47332. doi:10.1371/journal.pone.0047332

16. Giorgetti A., P. Ruggerone, S. Pantano, and P. Carloni, Advanced Computational Methods in Molecular Medicine, Journal of Biomedicine and Biotechnology, 2012: p. 709085.

17. Zanzoni, S.; Assfalg, M.; Giorgetti, A.; D'Onofrio, M.; Molinari, H.. Structural Requirements for Cooperativity in Ileal Bile Acid Binding Proteins. 2011. J Biol Chem. 2011 Nov 11;286(45):39307-17.

18. Modena, D.; Trentini, M.; Corsini, M.; Bombaci, A.; Giorgetti, A*. OlfactionDB: A Database of Olfactory Receptors and Their Ligands. Advances in Life Sciences 2011; 1(1): 9-13

19. Piccoli, S. and Giorgetti A*. Perspectives on Computational Structural Bio-Systems. J Bioproces Biotechniq 2011,1:104e

20. Biarnes X.; Marchiori A.; Giorgetti A.*; Lanzara C.; Gasparini P.; Carloni P.; Born S.; Brockhoff A.; Behrens M.; Meyerhof W. (2010). Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor. PLOS ONE, pp. 1- 6 Vol.5

21. Griguoli M.; Maul A.; Nguyen C.; Giorgetti A.; Carloni P.; Cherubini E. (2010). Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of orienslacunosum molecular interneurons. THE JOURNAL OF NEUROSCIENCE, pp. 10773- 10783 Vol.30

22. Heller D.M.; Giorgetti A.* (2010). NMR Constraints Analyser: a web-server for the graphical analysis of NMR experimental constraints. NUCLEIC ACIDS RESEARCH, pp. W628- W632 Vol.38

23. Saga G.; Giorgetti A.; Fufezan C.; Giacometti G.M.; Bassi R.; Morosinotto T. (2010). Mutation analysis of violaxanthin De-epoxidase identifies substrate-binding sites and residues involved in catalysis. THE JOURNAL OF BIOLOGICAL CHEMISTRY, pp. 23763- 23770 Vol.285

24. Mazzolini M.; Marchesi A.; Giorgetti A.; Torre V. (2010). Gating in CNGA1 channels. PFLUGERS ARCHIV, pp. 547- 555 Vol.459
- Previous: 2003 - 2009

25. Maullu C.; Raimondo D.; Caboi F.; Giorgetti A.; Sergi M;. Valentini M.; Tonon G.; Tramontano A. (2009). Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor. THE FEBS JOURNAL, pp. 6741- 6750 Vol.276

26. Lupieri P.;Nguyen C.H.H. ;Bafghi Z.G.;Giorgetti A.;Carloni P. (2009). Computational molecular biology approaches to ligand-target interactions. HFSP JOURNAL, pp. 228- 239 Vol.3

27. Raimondo D., Giorgetti A.+, Bernassola F., Melino G., Tramontano A. (2008). Modelling and molecular dynamics of the interaction between the E3 ubiquitin ligase Itch and the E2 UbcH7. BIOCHEMICAL PHARMACOLOGY, pp. 1620- 1627 Vol.76

28. Cozzetto D, Giorgetti A, Raimondo D, Tramontano A. (2008). The Evaluation of Protein Structure Prediction Results.. MOLECULAR BIOTECHNOLOGY, pp. 1- 8 Vol.39

29. Albiero E., Madeo D., Ruggeri M., Bernardi M., Giorgetti A., Rodeghiero F. (2008). Loss of the JAK2 intramolecular auto-inhibition mechanism is predicted by structural modeling of a novel exon 12 insertion mutation in a case of Idiopathic Erythrocytosis . BRITISH JOURNAL OF HAEMATOLOGY, pp. 986- 990 Vol.142

30. Tramontano, D. Cozzetto, A. Giorgetti, D. Raimondo.(2007) The assessment of methods for protein structure prediction. Methods in Molecular Biology 413, pp. 43-57

31. Moutran A, Balan A, Ferreira LC, Giorgetti A, Tramontano A, Ferreira RC. (2007). Structural model and ligand interactions of the Xanthomonas axonopodis pv. citri oligopeptide-binding protein. GENETICS AND MOLECULAR RESEARCH, pp. 1169- 1177 Vol.6

32. Tress, M., Martelli, P.L., Frankish, A., Reeves, G., Wesselink J.J., Yeats, C., Olason, P.I., Albrecht, M., Hegyi H., Giorgetti, A., Raimondo, D., Lagarde, J., Laskowski, R., Lopez, G., Sadowski, M.I., Watson, J., Fariselli, P., Rossi, I., Nagy, A., Kai, W., Stoerling, Z., Orsini, M., Assenov, Y., Blakenburg, H., Huthmacher, C., Ramirez, F., Schlicker, A., Denoued, F., Jones, P., Kerrien, S., Orchard, S., Birney, E., Brunak, S., Casadio, R., Guigo, R., Harrow, J., Hermjakob, H., Jones, D.T., Lengauer, T., Orengo, C., Patthy, L., Thornton, J., Tramontano, A., Valencia, A. 2007. The implications of alternative splicing in the ENCODE protein complement PROC. NATL ACAD SCI 104: 5495 - 5500

33. Giorgetti, A., Raimondo, D., Bosi, S. and Tramontano, A. 2007. An automatic procedure for using models of proteins in molecular replacement. PROTEINS. 15;66(3):689-96

34. Nair, A.V., Mazzolini,M., Codega, P., Giorgetti, A. and Torre, V. 2006. Locking CNGA1 channels in the open and closed state. BIOPHYSICAL J. 90: 3599-3607

35. Giorgetti, A., Raimondo, D., Miele, A. and Tramontano, A. 2005. Evaluating the usefulness of protein structure models for molecular replacement. BIOINFORMATICS. 21(suppl_2):ii72-ii76

36. Giorgetti A, Carloni P, Mistrik P, Torre V. A Homology Model of the Pore Region of HCN channels. BIOPHYSICAL J. 89(2):932-944.

37. Giorgetti, A., A.V. Nair, P. Codega, V. Torre and P. Carloni. 2005. Structural Basis of Gating of CNG channels. FEBS LETTERS. 579(9):1968-1972

38. Giorgetti, A., Carloni, P. 2003. Molecular Modeling of Ion Channels: Structural Predictions. Current Opinion in Chemical Biology. 7: 150-156

 

Book chapters

1. Musiani F, Rossetti G, Giorgetti A*, Carloni P. Chemosensorial G-proteins-coupled receptors: a perspective from computational methods. Adv Exp Med Biol. 2014;805:441-57.
2. Giorgetti A. and Carloni P. "Molecular Mechanics/Coarse-Grained models". 2014 pag 165 - 174. In 'Protein Modelling'; editor: Gábor Náray-Szab. Springer. ISBN: 978-3-319-09975-0
3. Giorgetti A., S. Piccoli, Knowledge Based Membrane Protein Structure Prediction: From X-Ray Crystallography to Bioinformatics and Back to Molecular Biology, in Current Trends in X-Ray Crystallography, edited by Annamalai Chandrasekaran, InTech Publisher (2011).
4. Tress M., Casadio R., Giorgetti A., Hallin PF., Juncker AS., Kulberkyte E., Martelli PL., Raimondo D., Reeves GA., Thornton JM., Tramontano A., Wang K., Wesselink JJ., Valencia A., Alternative Splicing in the ENCODE Protein- Complement , Frishman D., Valencia A. Modern Genome Annotation: the Biosapiens Network , Wienn , Springer-Verlag , 2008
5. Tramontano A., Jones D., Rychlewski L., Casadio R., Martelli PL., Raimondo D., Giorgetti A., Protein structure prediction, Frishman D., Valencia A. Modern Genome Annotation: the Biosapiens Network, Wienn , Springer-Verlag , 2008

 

Teaching activities

1. Institutional teaching activities at University of Verona.
2. Professor: 'Database search'. Master in Biotecnologie Bioinformatiche applicate alla Medicina personalizzata. Pula (CA) - Italy (June, 2007).
3. Professor: 'Structure Prediction'. Master in Biotecnologie Bioinformatiche applicate alla Medicina personalizzata. Pula (CA) - Italy (July, 2007).
4. Professor: 'Database search'. Master in Biotecnologie Bioinformatiche applicate alla Medicina personalizzata. Pula (CA) - Italy (June 5th - 15th, 2006).
5. Professor: 'Structure Prediction'. Master in Biotecnologie Bioinformatiche applicate alla Medicina personalizzata. Pula (CA) - Italy (July 3rd - 7th , 2006).
6. Tutor in the "Continuing Professional Development - Bioscience Programme" . Module: "The Experimental-Bioinformatics Interface - Key Issues in Protein Bioinformatics". Oxford - UK (16th to 20th January 20)
7. "Evaluating the usefulness of protein structure models for molecular replacement. ECCB 2005. Madrid - Spain (2005).
8. Instructor of the 3rd Biosapiens Permanent European School in Bioinformatics. Madrid - Spain (2005).
9. "Structural models of the hyperpolarization-activated and cyclic nucleotide gated channels". INFM (S3). Modena - Italy (2004).
10. Instructor of the First Biosapiens Permanent European School in Bioinformatics. Verona, Italy (2004).
11. "Structural models of HCN ion channels". CECAM Discussion Meeting 'Ion Channels: from Biology to Physic'. Lyon - France (2002).

 

Addresses

International School for Advanced Studies (SISSA/ISAS)
SISSA
Via Bonomea 265
34136 Opicina, Trieste
Italy
IAS-5 / INM-9
Computational Biomedicine
Forschungszentrum Jülich
Wilhelm-Johnen-Straße
52428 Jülich

Contact

Phone: +39 045 8027801
email: alejandro.giorgetti@univr.it

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