Dipl.-Phys. David Gräßel
Degree: Master of Science, RWTH Aachen
Polarized Light Imaging (3D-PLI) - High resolution imaging of nerve fiber tracts in the brain using polarized light.
The Connectome project dedicated to reveal the connectivity of interacting brain regions involves different neuroimaging techniques such as optical microscopy and diffusion weighted magnetic resonance imaging. Three-dimensional Polarized Light Imaging (3D PLI) is an innovative approach to map the spatial orientations of nerve fibers in unstained histological sections of the brain at the micrometer scale. The principle of 3D-PLI is based on the birefringent properties of the myelin sheaths surrounding nerve axons.
- 3D-Vectormapping of the fiber architecture (60 down to 1,6 microns)
- 3D-Animation and visualization of neuronal fiber models with Matlab®
- Fully automatized hardware programming with LabView®
- Theory of polarized light propagation in uniaxial birefringent tissue
AddressInstitute of Neuroscience and Medicine (INM-1)
Fax: +49 2461 61-3483