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Bild von Miriam Menzel

Miriam Menzel

PhD student at the INM-1, team Fibre Architecture
Academic degree: M.Sc. in Physics, RWTH Aachen

Area of Research

3D Polarized Light Imaging (3D-PLI) is a neuroimaging technique that reconstructs the three-dimensional pathways of nerve fibers in postmortem brains with a resolution at the micrometer scale: By transmitting polarized light through histological brain sections in a polarimeter, the birefringence of the nerve fibers is measured and the underlying fiber orientations are determined.

The reconstruction of the nerve fiber orientations is based on a macroscopic model of uniaxial birefringence which has not been investigated before. In order to better understand the physical mechanisms and processes in 3D-PLI and to verify the use of the macroscopic model, different analytical methods and numerical simulations are developed.

Methodical Key Aspects

  • Simulation of different fiber constellations
  • Theoretical description of physical effects
  • Development of analytical methods for a better signal analysis and fiber reconstruction
  • Investigation of form and intrinsic birefringence as well as other optical effects such as dichroism and scattering

Address

Institute of Neuroscience and Medicine (INM-1)
Forschungszentrum Jülich
52425 Jülich

Contact

Phone: +49 2461 61-9141
email: m.menzel@fz-juelich.de

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