M.Sc. Miriam Menzel
PhD student at the INM-1, team Fibre Architecture
Academic degree: M.Sc. in Physics, RWTH Aachen
Area of Research
3D Polarized Light Imaging (3D-PLI) is a neuroimaging technique that reconstructs the three-dimensional pathways of nerve fibers in postmortem brains with a resolution at the micrometer scale: By transmitting polarized light through histological brain sections in a polarimeter, the birefringence of the nerve fibers is measured and the underlying fiber orientations are determined.
The reconstruction of the nerve fiber orientations is based on a macroscopic model of uniaxial birefringence which has not been investigated before. In order to better understand the physical mechanisms and processes in 3D-PLI and to verify the use of the macroscopic model, different analytical methods and numerical simulations are developed.
Methodical Key Aspects
- Simulation of different fiber constellations
- Theoretical description of physical effects
- Development of analytical methods for a better signal analysis and fiber reconstruction
- Investigation of form and intrinsic birefringence as well as other optical effects such as dichroism and scattering
AddressInstitute of Neuroscience and Medicine (INM-1)
Fax: +49 2461 61-3483