Research fellow, Ph.D. student: University Wuppertal, Department of Physics
Degree: Diplom Ingenieur (FH)
Polarized Light Imaging (3D-PLI) - High resolution imaging of nerve fiber tracts in the human brain using polarized light
The Connectome project dedicated to reveal the connectivity of interacting brain regions involves different neuroimaging techniques such as optical microscopy and diffusion weighted magnetic resonance imaging. Three-dimensional Polarized Light Imaging (3D-PLI) is an innovative approach to map the spatial orientations of fiber tracts in histological sections of the human brain at a submillimeter scale. The basic principle of 3D-PLI is based on the birefringent properties of the myelin sheaths surrounding nerve axons.
- Characterization and study of the polarimeter of Polarized Light Imaging (PLI).
- Determination of the resolution and the reproducibility of measurements.
- Analysis of systematic errors.
AddressInstitute of Neuroscience and Medicine (INM-1)