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Master Projects: Microfluidic Single-Cell Physiology Analysis of Bacteria

Advertising institute: IBG-1 - Biotechnology
Reference number: D060/2014, Biology, biotechnology, biochemistry, biomedical sciences or similar

Background: Microfluidic devices harbor channels with dimensions less than a millimeter and are used by now for plenty of tasks and research fields in organic chemistry, biotechnology, chemical engineering and catalysis. Such “Lab-on-a-Chip” devices for single use are manufactured in a rapid and simple molding process using polymethylsiloxane (PDMS). Utilizing these biochips, growing bacteria can be observed on a single-cell basis.

About us: The research group “Microscale Bioengineering Group” is part of the Institute of Bio- and Geosciences (IBG-I: Biotechnology) located at the Forschungszentrum Jülich GmbH. The group is developing cutting edge microfluidics to perform applied microbial single-cell research. The young researchers group in an interdisciplinary environment offers the possibility to gain working experiences in single cell analysis.

Project description: Phenotypic heterogeneity on single cell level due to environmental changes or intrinsic effects of bacteria are of growing interest in microbiology and biotechnology research. Chosen microorganisms are cultivated under various growth conditions on chip and imaged by automated time lapse fluorescence microscopy. Experiments are then evaluated by computer aided image processing to derive single-cell growth, morphology, lineage and fluorescence data.

Requirements: We are looking for excellent and highly motivated students in their final year, studying biology, biotechnology, biochemistry, biomedical sciences or similar. The candidate should have a strong interest in multidisciplinary research. First experience with high-end microscopy and microfluidics technology would be highly beneficial.

Please send digital applications only (motivation letter, requested starting date and length, CV, transcripts, etc.: one single PDF file containing all documents). For more information and application please contact:

Dr. Dietrich Kohlheyer
IBG-1: Biotechnology
Microscale Bioengineering Group
Forschungszentrum Jülich GmbH
52425 Jülich, Germany

Phone:  +49 (0)2461-61-2875