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Doctoral Studies: Semisynthesis and Mutasynthesis

Advertising institute: IBG-1 - Biotechnology
Reference number: D062/2018, Biochemistry, Chemistry, Biotechnology

The Institute for Bioorganic Chemistry (Prof. Dr. Pietruszka) is a joint venture of the Heinrich Heine University Düsseldorf and the Forschungszentrum Jülich GmbH located on the research centre campus in Jülich. Our research is dedicated to selective syntheses of active agents, derivatives thereof and chiral building blocks. Therefore, we try to combine the advantages of preparative-organic chemistry and biocatalysis. Our co-workers try to harness the synergies of chemistry and biology for sustainable, synthetic purposes.

Your job:
The doctoral position (3 years) will be located at the interface of biosynthesis and synthetic chemistry of secondary metabolites. Natural compound derivatives will be generated by means of semi- and mutasynthesis in order to tailor their pharmacological properties. The synthesis-oriented project will include the following chemical and biochemical methods:

  • heterologous production and purification of natural products
  • syntheses of precursors for mutasynthesis applications and semisynthetic derivatisation
  • synthesis of reference compounds (inert chemistry, flash chromatography)
  • chemical analyses (NMR, MS, HPLC, GC etc.)

Besides the scientific aspects of the project, you will be integrated in our teaching responsibilities for biochemists and chemists (BSc and MSc).

Your profile:

  • finished master studies in biochemistry, chemistry, biology, biotechnology or comparable (final mark good/2.0 or better)
  • advanced experiences in synthetic chemistry
  • basic knowledge in biochemistry
  • languages: English (fluent), German (optional)
  • you must be curious, communicative, and reliable
  • interest in scientific publications

What we offer:

  • three year doctorate position (50% EG 13)
  • an interdisciplinary team (chemists, biochemists, biotechnologists)
  • scientific and transferrable skill courses
  • modern lab equipment
  • supportive supervision

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women. We also welcome applications from disabled persons.

If you have questions feel free to contact Dr. Sonja Meyer zu Berstenhorst.

Details for the application and a short form concerning your personal data can be downloaded here.
Applications lacking this form won't be considered. We are looking forward receiving your convincing application. The position is available as soon as possible.

After sending your application, Dr. Sonja Meyer zu Berstenhorst will check your application if something is missing and she will sent a reception mail including the next steps, however, this may take a few days because its no automatic mail. Thanks for staying patient.

If we caught your attention for this position, please visit our homepage for further positions and the application procedure at