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Advertising division: IBG-1 - Biotechnology
Reference number: D087/2018, Biochemistry, biology or biotechnology

PhD student position: Innovative tools for biocatalyst immobilization

The Institute of Molecular Enzyme Technology (IMET) is a department of Heinrich Heine University Düsseldorf (HHU) although not located in Düsseldorf but on the campus of the renowned Helmholtz research center Forschungszentrum Jülich GmbH (FZJ) in the triangle between Aachen, Cologne and Düsseldorf. The institute is embedded in close co-operations with the FZJ institutes IBG-1: Systemic Microbiology and IBG-1: Systems Biotechnology as well as the HHU institute IBOC (Institute of Bioorganic Chemistry).

The Molecular Biophotonics group at the Institute of Molecular Enzyme Technology (IMET) of the Heinrich Heine University Düsseldorf located at the Forschungszentrum Jülich offers a position for a doctoral student for the development of new tools for protein immobilization starting in June/July 2018.

Background:
Although the application of biocatalysis in industry has significantly increased in the last decade, biocatalytic steps are still not part of the common chemical repertoire. In order to make biocatalysts more attractive for routine application in chemical labs and industry, efficient, cheap and stable immobilization methods are required. In recent years, new immobilization concepts, utilizing a bottom-up synthetic biology approach, have been developed in our working group. Those concepts include the realization of inclusion body-based immobilizates and the use of affinity-binding domains for directed immobilization of enzymes on biogenic, water-insoluble carrier materials such as crystalline cellulose.

Your project:
You will develop and test new immobilization concepts for biocatalysts. Therefore different enzyme classes, which are well established in our working group, will be immobilized by different methods. The project involves cloning and expression of the respective enzyme constructs, lab-scale characterization of the immobilizates as well biocatalytic application.

Your profile:
The ideal candidate should have a Master degree in biochemistry, biology or biotechnology (or related) with a background in enzymology and protein chemistry. Knowledge of general molecular biological methods, microbiological techniques as well as good English communication skills are mandatory. Experience with protein engineering methods, immobilization techniques, and instrumental analysis of (chiral) compounds is advantageous.

Our offer:
We are a research group with excellent experimental equipment embedded in the international research environment of the Forschungszentrum Jülich. The Heinrich Heine University offers a doctorate program limited to three years including salary and social benefits conforming to the provisions of the Collective Agreement for the German Civil Service (salary scale: EG 13, 50%).

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women. We also welcome applications from disabled persons.

Contact/Question?
In case of questions concerning the project or organizational issues feel free to contact Dr. Ulrich Krauss (u.krauss@fz-juelich.de).

Application
Detailed application instructions and a short form concerning your personal data can be downloaded here. Applications lacking this form won't be considered. We are looking forward receiving your convincing application.

Please send your application (including all required documents, see instructions) to Dr. Ulrich Krauss (u.krauss@fz-juelich.de).


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