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Advertising division: ICS-6 - Structural Biochemistry
Reference number: D095/2018

PhD student position: Interaction of Amyloid-β protein with Amyloid-β fibrils

About us:
The Institute of Physical Biology (IPB) from the Heinrich Heine University in Düsseldorf (HHU) is co-operating closely with the Institute of Complex Systems (ICS-6): Structural Biochemistry from the Research Centre Jülich GmbH (FZJ). One of the main research topics of both institutes is related to Alzheimer’s disease and the role of the Amyloid-β protein in the onset and development of the disease. A PhD position is available as part of a collaboration between the two institutes.

Background:
The project goal is to elucidate the thermodynamics and structural description of Amyloid-β 1-42 and pyroglutamate-modified Amyloid-β 3-42 peptides binding to fibrils by using a combination of enhanced molecular dynamics (MD) simulations and various types of surface-based biosensing experiments, in particular surface plasmon resonance (SPR) and biolayer interferometry (BLI). The PhD project will offer the opportunity to also acquire expertise in further biophysical and biosensing techniques, as well as microfluidics.

Your profile:

  • The candidate should have a physics/chemistry background, preferably with experience in experimental methods and desire to learn various bio-simulation techniques.
  • Ideally he/she should have wet lab experience related to the Amyloid-β peptide or amyloidogenic proteins in general, including knowledge of biophysical methods.
  • Experience with enhanced MD simulations and free energy calculation methods is most welcome.

Our offer:

  • The PhD position is for 3 years starting in June/July and will be located at the Research Centre Jülich and at the Heinrich Heine University in Düsseldorf.
  • The student will be co-supervised by Dr. Bogdan Barz (FZJ/HHU) and Jun. Prof. Alexander Büll (HHU) and will be trained in both experimental and computational methods.
  • The salary and social benefits will be in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD, 65%).

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women. We also welcome applications from disabled persons.

Contact:
To apply please send a CV, a motivation letter and contact details of two references to b.barz@fz-juelich.de.

Dr. Bogdan Barz
Forschungszentrum Jülich
Institute of Complex Systems, ICS-6
Structural Biochemistry
52428 Jülich, Germany
Tel: +49 2461 619477
Fax: +49 2461 618766

Announcement as pdf file:  PhD student position: Interaction of Amyloid-β protein with Amyloid-β fibrils (PDF, 113 kB)