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Master’s thesis / Diploma thesis in Alzheimer’s research

Advertising institute: ICS-6 - Structural Biochemistry
Reference number: D118/2013, Biology

The research group “Therapy and diagnosis of Alzheimer’s disease” at the Institute for complex systems (ICS-6: Structural biochemistry) at Forschungszentrum Jülich

We are interested in the diagnosis and therapy of Alzheimer’s disease (AD). Aggregating proteins such as amyloid-β play a major role in the pathogenesis of AD. We have identified different peptides that are able to interfere with amyloid aggregation or unravel existing amyloid plaques. This seems to become a promising approach for AD therapy. Validation of the peptides is carried out in vivo with transgenic AD-mice which develop both amyloid plaques and cognitive deficits.

In the course of the Master’s or Diploma thesis the cognitive deficits of AD-mice will be compared to control mice. Afterwards, the animals will be treated with peptides and success of the treatment on cognitive deficits and amyloid plaque pathology will be examined. The applied tests are the “Morris water maze” and the “object recognition test” as well as histological techniques on cryo sections.

Literature example: Funke et al., Oral Treatment with the D-Enantiomeric Peptide D3 Improves Pathology and Behavior of Alzheimer's disease Transgenic Mice. ACS Chem. Neurosci. 1, 639-648 (2010).

Of our future colleague we expect a self-dependent and accurate way of working. We are looking for applicants with a high amount of initiative, motivation and team spirit as well as willingness to work with laboratory animals.

Experiences with laboratory animals, behavioural tests or histological techniques are desirable but not required.

We offer competent supervision and an excellently appointed lab at the Forschungszentrum Jülich.

For more Information please contact Dr. Antje Willuweit (phone: 02461-61-2984).
Please send your application with the usual documents via email to: a.willuweit@fz-juelich.de

Dr. Antje Willuweit
Forschungszentrum Jülich
52425 Jülich
Germany


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