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PhD thesis student (m/f): Investigations on the Molecular Origin of Multiple Sclerosis:
Interaction of Myelin Basic Protein with Model Membranes

Advertising institute: JCNS-1 - Neutron Scattering
Reference number: D142/2017, Chemistry, Physical Chemistry, Physics, Biophysics

The Jülich Centre for Neutron Science (JCNS) at the Heinz Maier-Leibnitz Zentrum (MLZ) develops and operates outstanding neutron scattering instruments at the best neutron sources in the world. Within our research fields „Soft Matter and Biophysics“ and „Correlated Electron Systems and Nanomagnetism“ we offer researchers from science and industry the use of these instruments including excellent sample environment and support laboratory infrastructure. A team of expert instrument scientists is ready for support. At JCNS-1 we are using neutron scattering for the investigation of structure and dynamics of soft matter and biophysics.

For the field of “Soft Matter and Biophysics” we are looking for a highly motivated

PhD thesis student (m/f)

Your Job:
The work is based in the field of neutron scattering and molecular biophysics. You will investigate the structure and dynamics of large-unilamellar vesicles (LUV) as model membranes for the disease of multiple sclerosis. Furthermore, you will study their interaction with membrane active proteins for basic research in health and medicine. The interaction of myelin basic protein (MBP) with LUV and the modification of the structural and dynamic properties of LUV by MBP binding will be investigated.

In your PhD project, you will study the basic properties of native and diseased membranes and their interaction with MBP under controlled conditions in vitro. Structural properties will be investigated by small-angle neutron and X-ray scattering (SANS & SAXS). Complementary information will be gained from cryo-electron microscopy (cryo-EM). Membrane dynamics will be studied by using neutron spin-echo spectroscopy (NSE). The position is based at the Heinz Maier-Leibnitz Zentrum (MLZ) in Garching close to Munich. A strong collaboration with the institute JCNS-1 is needed including regular business trips to Jülich.

Your Profile:
The ideal candidate should have a Master degree in Physics or Chemistry with a background in Soft Matter or Molecular Biophysics. Knowledge of scattering techniques is not required but would be a plus. Experience with computer programming for data analysis (python or similar) is advantageous. Good communication skills in English are a requirement. The applicant should have a cooperative and structured working style.

Our Offer:

  • International, interdisciplinary working environment on an attractive research campus close to Munich
  • Excellent scientific and technical infrastructure at MLZ
  • Optimal conditions for a successful PhD thesis in due time
  • Participation in national and international conferences
  • A comprehensive further training program
  • Flexible working hours and various opportunities to reconcile work and family life
  • Limited Position for 3 years
  • Salary and social benefits in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD).

Working location is Garching close to Munich.

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women.

We also welcome applications from disabled persons.

Please submit your application (including letter of motivation, CV and exam results as pdf files) to

Dr. Aurel Radulescu, email: a.radulescu@fz-juelich.de

not later than 31 December 2017.

Contact for further information and inquiries:
Dr. Aurel Radulescu, a.radulescu@fz-juelich.de
Dr. Andreas Stadler, a.stadler@fz-juelich.de

http://www.fz-juelich.de/ics/ics-1/EN
http://www.mlz-garching.de/kws-2


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