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Reference number: D164/2018, Medicine, biology

PhD position: Structural determinants of synaptic transmission and plasticity in the human neocortex

The group „Structure of Synapses“ (Head. Prof. Joachim Lübke) at the Institute of Neuroscience and Medicine INM-10, Research Centre Jülich GmbH offers a 3 years PhD-position (TvÖD E13/50-65%). We are interested in structural and molecular aspects of synaptic transmission and plasticity in the normal, developmental and pathologically altered rodent and human brain. We use state-of-the-art high-resolution light- and electron microcopy (Transmission- and Focussed Ion Beam scanning electron microscopy) and computer-assisted quantitative 3D reconstructions to develop quantitative 3D models of synapses embedded in the neocortex and hippocampus used as model systems. This models provide the basis for numerical and/or MonteCarlo simulations of various synaptic parameters still inaccessible to experiments.

In a second research project we are interested in the density, distribution and possible co-localization of calcium ion channels, neurotransmitter receptors and their subunits and synaptic transporter and other proteins at the so-called active zone at synapses that at the molecular level drive synaptic transmission and plasticity. This is achieved with single- and multiple pre- and postembedding immunohistochemistry on ultrathin sections or freeze fracture replica preparations.

The candidate will work with state-of-the-art light- and electron microscopic techniques including all preparatory work, modern immunohistochemical pre- and postembedding technique and computing. Requirements: completed master's degree in medicine or biology, knowledge in basic neuroscience, laboratory and computational skills, high motivation in learning new technics, ability to work in a team, good english language skills.

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women. We also welcome applications from disabled persons.

Applications with the common application documents should be send to:
Prof. Dr. Joachim Lübke
Institute of Neuroscience und Medicine INM-10
Forschungszentrum Jülich GmbH.

Tel.: 02461/612288;
e-mail: j.luebke@fz-juelich.de