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Postdoc (m/f) in the field of Single molecule fluorescence microscopy

Advertising institute: ICS-5 - Molecular Biophysics
Reference number: 2014-132

Physicists, Biologists, and Biophysicists work together at the ICS-5 to deepen our knowledge on the structure, dynamics and function of complex biomacromolecular assemblies with state-of-the-art equipment at the interface between physics and molecular biology. Our goal is to employ fluorescence based methods to study protein properties and interactions with a high sensitivity and selectivity. In particular single molecule techniques provide information on the distribution of parameters characterizing the biological macromolecules. With this position, we are aiming to strengthen our expertise in the field of single molecule imaging and single molecule spectroscopy. The successful candidate should contribute to our research activities in the field of single molecule FRET studies with surface tethered molecules.

We are looking to recruit a

Postdoc (m/f) in the field of Single molecule fluorescence microscopy

Your Job:

Your main duties are research and development in the field of single molecule fluorescence based techniques. You will be part of a team using state-of-the-art equipment (TIRF microscope for simultaneous dual color imaging, confocal microscope with pulsed excitation and multi-channel detection) which investigates structural and dynamical properties of proteins and protein complexes. Here issues, like functional protein dynamics, protein folding and membrane protein interactions are in the focus of our activities. In addition, the development of vitro assays for studying cellular processes (or parts of these processes) in real time and in situ is envisioned. This also includes to application of nano-apertures like zero mode waveguides (ZMWs) to study protein ligand interactions at physiological relevant concentrations on single molecule level. The results of your research are expected to be published in international peer reviewed journals. Interdisciplinary teamwork, as well as the supervision of Master and PhD students is expected.

Your Profile:

  • A higher degree in Physics, Chemistry or Biochemistry and a Doctorate in a related field
  • Extensive knowledge of high resolution fluorescence microscopy and spectroscopy
  • Comprehensive experience in conducting research projects in structural biology by using fluorescence based single molecule techniques.
  • The willingness to participate in already existing projects and to identify new projects worth to be established in the institute
  • The ability to communicate and work effectively in an interdisciplinary team
  • A structured and systematic approach to problem solving

Our Offer:

  • An interdisciplinary and international collegial work environment
  • If successful, the potential for building a junior research group
  • Located in the border region between Belgium, Germany, and the Netherlands, Forschungszentrum Jülich is embedded in the ABCD Region (Aachen, Bonn, Cologne, Dusseldorf), one of Europe’s High-Tech Centers


  • limited for 2 years
  • Full-time position with the option of slightly reduced working hours
  • Salary and social benefits in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD).


Forschungszentrum Jülich aims to employ more women in this area and therefore particulary welcomes applications from women.

We also welcome applications from disabled persons.

We look forward to receiving your application, preferably online via our online recruitment system, quoting the above-mentioned reference number.

Contact P-E
Gerda Crützen
Tel.:02461 61-9700


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