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Advertising division: ICS-6 - Structural Biochemistry
Reference number: 2019-042


The function of each cell and organism depends crucially on the dynamic interactions between biological macromolecules and their correct three-dimensional structure. Faulty interactions and misfolded structures ultimately lead to disease and aging. The goal of ICS-6 is to understand these interactions and to determine the three-dimensional structures of the protein complexes involved in crucial cellular processes as far as possible at atomic resolution. In addition, the department is developing novel methods for the early detection and therapy of neurodegenerative diseases with a strong focus on Alzheimer´s dementia.

We are looking to recruit a

Postdoc in Computational Biochemistry

Your Job:

The Computational Biochemistry Group, which is headed by Prof. Birgit Strodel, is part of the ICS-6 and focuses on the development and application of computational methods for studying protein aggregation. The research topic of the project deals with the further development of a hybrid all-atom/coarse-grained simulation approach for studying Alzheimer´s amyloid-ß peptide in complex biological environments. This will allow unexpected new insight into the aggregation of amyloid-ß under near-native conditions. Tasks:

  • Further development of a hybrid all-atom/coarse-grained model for amyloid peptides.
  • Implementation of the resulting model into Gromacs.
  • Application of the resulting model to simulate amyloid aggregation in complex environments.
  • Cooperation with experimentalists to validate and address resulting findings.

Your Profile:

  • A strong PhD degree in computational/theoretical biochemistry/biophysics or related
  • Expert knowledge in the simulation of proteins at the atomistic and/or coarse-grained level using GROMACS or similar software
  • Experience in method development, in particular in force field development
  • Strong programming and scriptng skills (e.g., Python, C/C++, bash)
  • Profound spoken and written English skills
  • Being creative, ambitious, highly motivated
  • Ability to work independently

Our Offer:

  • Exciting working environment on an attractive research campus with excellent infrastructure, located between the cities of Cologne, Düsseldorf, and Aachen
  • International and interdisciplinary working atmosphere
  • A comprehensive further training programme
  • Flexible working hours and various opportunities to reconcile work and private life
  • Limited for 2 years with possible longer-term prospects
  • Full-time position with the option of slightly reduced working hours
  • Salary and social benefits in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD). Depending on the applicant's qualifications and the precise nature of the tasks, salary grade 13 TVöD-Bund

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women.

We also welcome applications from disabled persons.

Additional Information

We look forward to receiving your application, preferably online via our online recruitment system on our career site until 10.03.2019, quoting the above-mentioned reference number.

Questions about the vacancy?
Contact us by mentioning the reference number 2019-042:
Please note that for technical reasons we cannot accept applications via email.