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IAS Seminar "A Hidden Trigger of Alzheimer’s Disease in Diabetes"

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18 Mar 2016 10:00
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18 Mar 2016 11:00
venue
Jülich Supercomputing Centre, Rotunda, building 16.4, room 301
Speaker:
Florin Despa, Ph.D., Associate Professor, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, USA
Abstract:
Amylin is a hormone synthesized and co-secreted with insulin by pancreatic islets that crosses the blood brain barrier and regulates satiety. Amylin from humans (but not rodents) has an increased propensity to aggregate into pancreatic islet amyloid deposits that contribute to the development of type-2 diabetes by inducing oxidative stress and inflammation. In my talk, I will present experimental results from my lab showing that elevated circulating levels of aggregated amylin negatively affect the neurons causing peroxidative membrane injury and aberrant inflammatory responses independent of other confounding factors of diabetes. In addition, amylin interacts with β amyloid (A β) forming mixed amylin-Aβ oligomers and plaques. Present results demonstrate a novel contributing mechanism to neurodegeneration and suggest a direct, potentially treatable link of type-2 diabetes with Alzheimer’s disease.
Date:
Friday, 18 March 2016, 10:00
Venue:
Jülich Supercomputing Centre, Rotunda, building 16.4, room 301
Announcement as pdf file:
 A Hidden Trigger of Alzheimer’s Disease in Diabetes (PDF, 36 kB)

Anyone interested is cordially invited to participate in this seminar.
Contact: Dr. Jan Meinke, j.meinke@fz-juelich.de

 


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