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Seminar by Dr. Kristin Reiche

Helmholtz Centre for Environmental Research, UFZ, Leipzig (Germany)

17 Mar 2014 10:00
17 Mar 2014 11:00
Lecture room 2009, Jülich GRS building (16.15)

Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long non-coding RNAs

Genome-wide transcriptome studies, like ENCODE and FANTOM, demonstrated that only a minor fraction of eukaryotic transcriptomes is translated into proteins, whereas the majority is dominated by transcripts that do not code for proteins. Many of these non-protein coding RNAs (ncRNAs) display specific expression in dependence of cell type or tissue, hence are likely to be functional and to participate in a wide range of molecular processes. The class of small ncRNAs has already been studied in great detail, but the function of the larger heterogeneous group of long ncRNAs (lncRNAs) is less well characterised and less well understood. Despite an increasing number of reports on the function of individual lncRNAs, it is difficult to assess the extent of functional transcripts among the vast non-coding transcriptional output of mammalian cells.
We have identified long ncRNAs and macro ncRNAs which are differentially expressed (i) throughout cell cycle progression, in response to (ii) the anti-proliferative and pro-apoptotic p53 pathway, and (iii) the anti-apoptotic and pro-proliferative STAT-3 pathway. We finally investigated the association of these ncRNAs with tumor diseases.