JPSS Jülich Plant Science Seminar Series:
Prof. Dr. Bernd Müller-Röber, University of Potsdam
- 12.11.2013 10:30 Uhr
- Forschungszentrum Jülich, Gebäude 06.2 IBG-2, Seminarraum 406, 2.Stock
Dissecting the gene regulatory networks of plant transcription factors
The control of gene expression is fundamental to almost all biological processes and requires the action of specific DNA-binding proteins, so-called transcription factors (TFs), which interact with cis-regulatory motifs in the promoters of target genes. TFs and their targets form gene regulatory networks (GRNs) that function in development- and condition-specific ways and are often key elements of regulatory feed-back or feed-forward loops. Our group uses a combination of experimental and computational methods to unravel the roles of TFs for life span control, abiotic stress tolerance and organ size regulation in plants. A major focus of our activity lies on the analysis of NAC transcription factors, several of which are rapidly and strongly induced by reactive oxygen species (ROS), including hydrogen peroxide (H2O2), indicating a role in ROS signalling. We identified target genes for various Arabidopsis NAC TFs giving insights into their regulatory circuits and biological functions. I will present our general working strategy and give specific examples for selected NAC TFs.
Selected recent publications:
Schmidt R, Schippers JH, Mieulet D, Obata T, Fernie AR, Guiderdoni E, Mueller-Roeber B. (2013) MULTIPASS, a rice R2R3-type MYB transcription factor, regulates adaptive growth by integrating multiple hormonal pathways. Plant J., 76: 258-273.
Schmidt R, Mieulet D, Hubberten HM, Obata T, Hoefgen R, Fernie AR, Fisahn J, San Segundo B, Guiderdoni E, Schippers JH, Mueller-Roeber B. (2013) SALT-RESPONSIVE ERF1 regulates reactive oxygen species dependent signaling during the initial response to salt stress in Rice. Plant Cell 25(6):2115-31
Rauf M, Arif M, Dortay H, Matallana-Ramírez LP, Waters MT, Gil Nam H, Lim PO, Mueller-Roeber B, Balazadeh S. (2013) ORE1 balances leaf senescence against maintenance by antagonizing G2-like-mediated transcription. EMBO Rep. 14(4):382-8.
Mehrnia M, Balazadeh S, Zanor MI, Mueller-Roeber B. (2013) EBE, an AP2/ERF transcription factor highly expressed in proliferating cells, affects shoot architecture in Arabidopsis. Plant Physiol. 162(2):842-57.
Lai AG, Doherty CJ, Mueller-Roeber B, Kay SA, Schippers JH, Dijkwel PP. (2012) CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proc. Natl. Acad. Sci. USA 109(42):17129-34.
Wu A, Allu AD, Garapati P, Siddiqui H, Dortay H, Zanor MI, Asensi-Fabado MA, Munné-Bosch S, Antonio C, Tohge T, Fernie AR, Kaufmann K, Xue GP, Mueller-Roeber B, Balazadeh S. (2012) JUNGBRUNNEN1, a reactive oxygen species-responsive NAC transcription factor, regulates longevity in Arabidopsis. Plant Cell 24(2):482-506.
Contact: Prof. Dr. Ulrich Schurr