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ICS-2 Talk: Physics of epithelial flows and folds

Guillaume Salbreux, The Francis Crick Institute, London


Anfang
15.11.2018 11:00 Uhr
Veranstaltungsort
Gebäude 04.16, Raum 2001

Abstract:

The shape of a biological tissue is determined by mechanical stresses acting within the tissue cells. During embryonic morphogenesis, forces generated in the actomyosin cytoskeleton in the cells of epithelia result in cell deformation, cell rearrangements, and 3D bending of the epithelium. To understand tissue morphogenesis, force generation at the cellular scale must be related to flows and deformation occurring at the tissue scale. Here I will discuss how this relation can be captured by cell-based simulations and continuum theories of flows in surfaces. Using this framework, I will describe how two different mechanisms, basal relaxation and lateral constriction, can account for fold formation in the Drosophila wing disc. I will also discuss how planar tissue flows and interface deformation are related to cell shape changes and cell division, and show how the growth of the Drosophila histoblast nests can be decomposed into basic cellular events.

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PD Dr. Jens Elgeti
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