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ICS-3 Group Seminar:
Electrostatic energy of glutamates boosts synchronized exocytosis in a group of vesicles

Dr. Seol Ah Park

Chungam National University, Dept. of Physics, Daejon, South Korea

begin
29 Jan 2018 10:30
end
29 Jan 2018 11:30
venue
Seminarraum A1-3, Building 04.6, Entrance E1

Abstract:

The mechanism of signal transmission in inner hair cells is still elusive, therefore causes of peculiar signal patterns such as large EPSCs peaks and multiphasic EPSCs are unclear. We propose an energy-based model for exocytosis of multiple vesicles. We introduce electrostatic energy caused by negatively charged glutamates and ions in electrolytes, and mechanical energy which are regulated by calcium concentration. We find that the electrostatic energy acts as lowering the total system energy. A group of vesicles shows synchronized exocytosis with electrostatic energy, whereas vesicles tend to fuse individually only with the sufficient mechanical energy. We expect that our model is a good explanation for synaptic transmission of multiple vesicles system and the model can be applicable to inner hair cells.

Contact

Prof. Dr. Gerhard Naegele
Phone: +49 2461 61-2504
Fax: +49 2461 61-2280
email: g.naegele@fz-juelich.de

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