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BioSoft-Colloquium: "Virion Ion Channels - Sliding in 2D"

Prof. Dr. Wolfgang Fischer, National Yang-Ming University, Taipei, Taiwan

16.06.2014 14:00 Uhr



Viruses manipulate invaded cells to spur their own replication. Replication needs, amongst other steps, the alteration of electrochemical gradients across subcellular and cellular membranes. Proteins are included in the genomes of many viruses, which self-assemble and form ion conducting channels to full fill the task. The characteristics of these channels are hardly elucidated to date. Nevertheless, one protein has already been used as target in antiviral therapy, others are about to emerge as targets. The mechanism of function of viral channels is seen in a two-step scenario within the 2D array of the lipid membrane: generation of (i) the monomer, followed by the assembly of (ii) the oligomer, or ion conducting bundle. Computational models built along this line are presented for p7 of HCV. Putative ion dynamics around the channel is elucidated. The data are compared with those derived from computational models of the pore region of the Ca-ion conducting skeletal ryanodine receptor (RyR).


IFF lecture hall (Building 04.8, room 365)


Prof. Dr. Dieter Willbold
Institute of Complex Systems (ICS)
ICS-6: Structural Biochemistry