ICS-7 - Seminar
- 29.Apr.2014 09:00
Talk: Dr. Michael Rose, Institut für Pathologie, AG Molekulare Pathologie, Universitätsklinikum der RWTH Aachen
Title: Characterization of molecular mechanisms driving cancer metastasis
Venue: Seminar room ICS-7/PGI-3, Building 02.4w, Room 309b
Abstract: Metastasis is known to occur rapidly after tumor development and is responsible for high mortality rates of malignant diseases such as breast cancer. Metastasis is a multistep cascade, involving five steps: (1) Initial invasion of tumor cells into surrounding stroma, (2) intravasation, (3) blood circulation, (4) extravasation, and finally (5) micro- and macroscopic colony growth at distant organs. In-depth understanding of mechanisms driving metastatic processes is inevitable to develop novel therapeutic approaches. In recent years accumulating studies revealed that critical factors of early metastatic steps encode proteins which are associated with the extracellular matrix (ECM) affecting cancer cell adhesion, ECM turnover, migration or crucial cellular differentiation processes such as the epithelial-to-mesenchymal transition (EMT). Given that, we aim to characterize players involved in modulating ECM composition or epithelial plasticity based on in vitro and in vivo tumor models that give novel insight into molecular pathways contributing to metastatic diseases.