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Zeitschriftenbeiträge 2012

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Hydroxynitrile lyases with alpha/beta-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms
ChemBioChem 13, 1932 - 1939 (2012) [10.1002/cbic.201200239]  GO

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Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
Proceedings of the National Academy of Sciences of the United States of America 109(28), 11354 - 11359 (2012) [10.1073/pnas.1205735109]  GO

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A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level
Genome Biology 13, R40 (2012) [10.1186/gb-2012-13-5-r40]  GO

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Two-component signal transduction in Corynebacterium glutamicum and other corynebacteria: on the way towards stimuli and targets
Applied Microbiology and Biotechnology 94, 1131 - 1150 (2012) [10.1007/s00253-012-4060-x]  GO

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MuteinDB: the mutein database linking substrates, products and enzymatic reactions directly with genetic variants of enzymes
Database 2012(0), bas028 - bas028 (2012) [10.1093/database/bas028]  GO

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Directed Evolution of P 450 BM 3 into a p-Xylene Hydroxylase
ChemCatChem 4(6), 771-773 (2012) [10.1002/cctc.201200092]  GO

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Functional implementation of the posttranslational SecB-SecA protein-targeting pathway in Bacillus subtilis
Applied and environmental microbiology 78, 651 - 659 (2012) [10.1128/AEM.07209-11]  GO

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Semi-automatic drawing of Metabolic networks
Information visualization 11, 171 - 187 (2012) [10.1177/1473871611413565]  GO

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Zonal rate model for stacked membrane chromatography part II: characterizing ion-exchange membrane chromatography under protein retention conditions
Biotechnology & bioengineering 109, 615 - 629 (2012) [10.1002/bit.24349]  GO

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Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB
Nature Communications 3, 1311 - (2012) [10.1038/ncomms2308]  GO

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Specific Association of Lectin LecB with the Surface of Pseudomonas aeruginosa: Role of Outer Membrane Protein OprF
PLoS one 7(10), e46857 - (2012) [10.1371/journal.pone.0046857]  GO

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Influence of organic solvents on enzymatic asymmetric carboligations
Advanced synthesis & catalysis 354(14-15), 2805–2820 (2012) [10.1002/adsc.201200284]  GO

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A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level
Lab on a chip 12, 2060 - 2068 (2012) [10.1039/c2lc40156h]  GO

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Femtoliter Growth Channels: Bacteria Long-Term Growth Patterns Analysis on Singel Cell Level
ProcessNet-Jahrestagung 2012 und 30. DECHEMA-JT 2012, Karlsruhe, Germany, 09/10/2012 - 09/13/2012 Chemie - Ingenieur - Technik: CIT 84(8), 1407 (2012) [10.1002/cite.201250343]  GO

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High-Throughput Growth Rate Determination of Bacteria Micro colonies on Single Cell Level
ProcessNet Jahrestagung 2012 und 30. DECHEMA-JT 2012, Karlsruhe, Germany, 09/10/2012 - 09/13/2012 Chemie - Ingenieur - Technik: CIT 84(8), 1336-1337 (2012) [10.1002/cite.201250342]  GO

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Influence of oxygen limitation, absence of the cytochrome bc1 complex and low pH on global gene expression in Gluconobacter oxydans 621H using DNA microarray technology
Journal of biotechnology 157, 359 - 372 (2012) [10.1016/j.jbiotec.2011.12.020]  GO

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Expressionsoptimierung in Mikroorganismen
Biospektrum 18, 449 - 451 (2012) [10.1007/s12268-012-0207-7]  GO

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The two-component system ChrSA is crucial for haem tolerance and interferes with HrrSA in haem-dependent gene regulation in Corynebacterium glutamicum
Microbiology 158(Pt 12), 3020 - 3031 (2012) [10.1099/mic.0.062638-0]  GO

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Polyketide Proofreading by an Acyltransferase-like Enzyme
Chemistry & biology 19(3), 329-339 (2012) [10.1016/j.chembiol.2012.01.005]  GO

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Conversion of Corynebacterium glutamicum from an aerobic respiring to an aerobic fermenting bacterium by inactivation of the respiratory chain
Biochimica et biophysica acta / Bioenergetics 1817, S130–S131 (2012) [10.1016/j.bbabio.2012.06.347]  GO

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Physiology and global gene expression of a Corynebacterium glutamicum ΔF1FO-ATP synthase mutant devoid of oxidative phosphorylation
Biochimica et biophysica acta 1817, 370 - 380 (2012) [10.1016/j.bbabio.2011.10.006]  GO

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Regulation of the malic enzyme gene malE by the transcriptional regulator MalR in Corynebacterium glutamicum
Journal of biotechnology 159(3), 204 - 215 (2012) [10.1016/j.jbiotec.2012.01.003]  GO

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Stereoselective synthesis of bulky 1,2-diols with alcohol dehydrogenases
Catalysis Science & Technology 2, 1580 - 1589 (2012) [10.1039/c2cy20120h]  GO

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Lrp of Corynebacterium glutamicum controls expression of the brnFE operon encoding the export system for l-methionine and branched-chain amino acids
Journal of biotechnology 158(4), 231 - 241 (2012) [10.1016/j.jbiotec.2011.06.003]  GO

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Genetic evidence for a tight cooperation of tatB and tatC during productive recognition of twin-argine (tat) signal peptides in Escherichia coli
PLoS one 7(6), e39867 (2012) [10.1371/journal.pone.0039867]  GO

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A tetracycline inducible expression vector for Corynebacterium glutamicum allowing tightly regulable gene expression
Plasmid 68(2), 142 - 147 (2012) [10.1016/j.plasmid.2012.05.001]  GO

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Toward homosuccinate fermentation: metabolic engineering of Corynebacterium glutamicum for anaerobic production of succinate from glucose and formate
Applied and environmental microbiology 78, 3325 - 3337 (2012) [10.1128/AEM.07790-11]  GO

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Efficient aerobic succinate production from glucose in minimal medium with Corynebacterium glutamicum
. Microbial Biotechnology 5, 116 - 128 (2012) [10.1111/j.1751-7915.2011.00310.x]  GO

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Phosphorothioate-based DNA recombination: an enzyme-free method for the combinatorial assembly of multiple DNA fragments
BioTechniques , 1-6 (2012) [10.2144/000113865]  GO

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Differential Arabinan Capping of Lipoarabinomannan Modulates Innate Immune Responses and Impacts T Helper Cell Differentiation
The journal of biological chemistry 287(53), 44173 - 44183 (2012) [10.1074/jbc.M112.402396]  GO

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Deletion of manC in Corynebacterium glutamicum results in a phospho-myo-inositol mannoside- and lipoglycan-deficient mutant
Microbiology 158(Pt_7), 1908 - 1917 (2012) [10.1099/mic.0.057653-0]  GO

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The ppm Operon Is Essential for Acylation and Glycosylation of Lipoproteins in Corynebacterium glutamicum
PLoS one 7(9), e46225 - (2012) [10.1371/journal.pone.0046225]  GO

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The development and application of a single-cell biosensor for the detection of L-methionine and branched-chain amino acids
Metabolic engineering 14, 449 - 457 (2012) [10.1016/j.ymben.2012.02.002]  GO

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Tailoring a Stabilized Variant of Hydroxynitrile Lyase from Arabidopsis thaliana
ChemBioChem 13, 797 - 802 (2012) [10.1002/cbic.201100619]  GO

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Detection, Quantification, and Propagation of Uncertainty in High-Throughput Experimentation by Monte Carlo Methods
Chemical engineering & technology 35, 1456 - 1464 (2012) [10.1002/ceat.201100610]  GO

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Model-integrated process development demonstrated on the optimization of a robotic cation exchange step
Chemical engineering science 76, 129 - 139 (2012) [10.1016/j.ces.2012.04.004]  GO

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Optimizing a chromatographic three component separation: a comparison of mechanistic and empiric modeling approaches
Journal of chromatography / A 1237, 86 - 95 (2012) [10.1016/j.chroma.2012.03.029]  GO

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Determination of parameters for the steric mass action model - A comparison between two approaches
Journal of chromatography / A 1233, 54 - 65 (2012) [10.1016/j.chroma.2012.02.004]  GO

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Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms
Microbial cell factories 11(1), 122 (2012) [10.1186/1475-2859-11-122]  GO

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Phenotypic Sorting and Analysis of Bacteria ProductionStrains Using Optical Tweezers and Microfluidics
ProcessNet Jahrestagung 2012 und 30. DECHEMA-JT 2012, Karlsruhe, Germany, 09/10/2012 - 09/13/2012 Chemie - Ingenieur - Technik: CIT 84(8), 1344 (2012) [10.1002/cite.201250339]  GO

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Mutational Analysis of the Pentose Phosphate and Entner-Doudoroff Pathways in Gluconobacter oxydans Reveals Improved Growth of a Δedd Δeda Mutant on Mannitol
Applied and environmental microbiology 78, 6975 - 6986 (2012) [10.1128/AEM.01166-12]  GO

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An automated workflow for enhancing microbial bioprocess optimization on a novel microbioreactor platform
Microbial cell factories 11(1), 144 (2012) [10.1186/1475-2859-11-144]  GO

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dRTP and dPTP a complementary nucleotide couple for the Sequence Saturation Mutagenesis (SeSaM) method
Journal of molecular catalysis / B 84, 40 - 47 (2012) [10.1016/j.molcatb.2012.04.018]  GO

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Synthesis of chiral cyanohydrins with recombinant Escherichia coli cells in a micro-aqueous reaction system
Applied and environmental microbiology 78, 5025 - 5027 (2012) [10.1128/AEM.00582-12]  GO

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TTC-based screening assay for omega-transaminases: A rapid method to detect reduction of 2-hydroxy ketones
Journal of biotechnology 159, 188 - 194 (2012) [10.1016/j.jbiotec.2011.12.023]  GO

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Engineering yield and rate of reductive biotransformation in Escherichia coli by partial cyclization of the pentose phosphate pathway and PTS-independent glucose transport
Applied Microbiology and Biotechnology 93, 1459 - 1467 (2012) [10.1007/s00253-011-3626-3]  GO

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Biocatalytic hydroxylation of n -butane with in situ cofactor regeneration at low temperature and under normal pressure
Beilstein journal of organic chemistry 8, 186 - 191 (2012) [10.3762/bjoc.8.20]  GO

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Error Propagation Analysis for Quantitative Intracellular Metabolomics
Metabolites 2(4), 1012 - 1030 (2012) [10.3390/metabo2041012]  GO

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Improved L-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity
Biotechnology & bioengineering 109, 2070 - 2081 (2012) [10.1002/bit.24486]  GO

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MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
Chemistry & biology 19(4), 498 - 506 (2012) [10.1016/j.chembiol.2012.03.006]  GO

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Quantification of proteome dynamics in Corynebacterium glutamicum by 15N-labeling and selected reaction monitoring
Journal of proteomics 75(9), 2660 - 2669 (2012) [10.1016/j.jprot.2012.03.020]  GO

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Surface bound adsorption in a microfluidic T-sensor: Numerical comparison and optimization of 2D and 3D models and a sensor designs
Sensors and actuators / B 170, 75–81 (2012) [10.1016/j.snb.2011.01.057]  GO

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Corynebacterium glutamicum harbours a molybdenum cofactor-dependent formate dehydrogenase which alleviates growth inhibition in the presence of formate
Microbiology 158(Pt 9), 2428 - 2439 (2012) [10.1099/mic.0.059196-0]  GO

Dissertationen 2012


Regulatorische Aspekte der Expression und Sekretion heterologer Proteine in Corynebacterium glutamicum
Schriften des Forschungszentrums Jülich : Gesundheit / Health 62, 179 p. (2012)


Modelica-Based Computational Tools for Sensitivity Analysis via Automatic Differentiation
220 p. (2012)


Untersuchungen zur Membranintegrität während der Tat-abhängigen Proteintranslokation in Escherichia coli
Schriften des Forschungszentrums Jülich : Gesundheit / Health 60, 155 p. (2012)


Einfluss unkonventioneller Medien auf die Selektivität ThDP-abhängiger Enzyme
Schriften des Forschungszentrums Jülich : Schlüsseltechnologien / Key Technologies 54, 199 pp. (2012)


Charakterisierung und Validierung der 13C-Stoffflussanalyse im Parallelansatz
(2012)


Eine kritische Evaluierung FRET-basierter Biosensoren als Werkzeug für die quantitative Metabolitanalytik
Schriften des Forschungszentrums Jülich : Gesundheit / Health 54, (2012)


Optimierung der Hydroxynitril-Lyase aus Arabidopsis thaliana für die enantio-selektive Synthese von (R)-Cyanhydrinen - Entwicklung und Etablierung geeigneter Reaktionsparameter und molekulare Stabilisierung durch rationales Enzymdesign
Schriften des Forschungszentrums Jülich : Gesundheit / Health 53, (2012)


Metabolomanalyse von Mikroorganismen – Methodenetablierung und Konzepte zur Automatisierung
(2012)


Prozessnahe Hochdurchsatzoptimierung der heterologen Proteinproduktion in alternativen Wirtsorganismen
Schriften des Forschungszentrums Jülich : Gesundheit / Health 58, (2012)


Untersuchungen zur sekretorischen Proteingewinnung industriell relevanter Enzyme mit Corynebacterium glutamicum
Schriften des Forschungszentrums Jülich : Gesundheit / Health 56, (2012)


Increasing the NADPH supply for whole-cell biotransformation and development of a novel biosensor
94 (2012)

Abgeschlossene Master-, Bachelor- und Diplomarbeiten 2012

Master Thesis

Expression von QConCat-Standardproteinen für die absolute Quantifizierung von Enzymen im Zentralstoffwechsel von Corynebacterium glutamicum
(2012)

Diploma Thesis

Entwicklung und Charakterisierung von integrierten Polydimethylsiloxan-basierten Ventilen und Pumpen für den Einsatz in der mikrofluidischen Einzelzellanalyse
108 p. (2012)

Master Thesis

Untersuchungen zur Exzision des CGP3 Prophagen in Corynebacterium glutamicum
(2012)

Master Thesis

Corynebacterium glutamicum: Metabolic impact of inhomogeneous oxygen supply conditions
88 p (2012)

Master Thesis

A (semi-)automatic image analysis approach to lineage tree generation from time-lapse microscopy
(2012)

Diploma Thesis

Konstruktion und Anwendung destabilisierter Fluoreszenzproteine in Corynebacterium glutamicum
(2012)

Diploma Thesis

Parametersensitivitäten für Chromatographiemodelle mit IDAS und kontinuierlichen Adjungierten
(2012)

Bachelor Thesis

In vitro- und in vivo-Effekte der Peptidyl-prolyl-Isomerase FkpA aus Corynebacterium glutamicum
(2012)

Master Thesis

Optimierung des Glucose-Stoffwechsels von Gluconobacter oxydans 621H Δupp durch Metabolic Engineering
(2012)

Bachelor Thesis

Penicillin V Produktion in Penicillium chrysogenum - Prozessentwicklung und 13C-Markierungsexperiment
(2012)

Master Thesis

Monte Carlo Methods in Systems Biology
(2012)

Master Thesis

Charakterisierung der endogenen Methanoloxidation in Corynebacterium glutamicum
(2012)

Master Thesis

Populationheterogeneity of Corynebacterium glutamicum - Method development and detection of subpopulations during cultivation
(2012)

Master Thesis

Metabolomanalyse von Penicillium chrysogenum: Glucose- und Gluconatstoffwechsel
(2012)

Bachelor Thesis

Einfluss von heterologen Faltungsfaktoren auf die Effizienz der Proteinsekretion des Gram-positiven Bakteriums Corynebacterium glutamicum
66 pp (2012)

Bachelor Thesis

Untersuchung der Stereoselektivität und des Substratspektrums von AHASI & II aus Escherichia coli
(2012)

Master Thesis

Extending the Model Library and Improving Numerical Aspects of the Chromatography Model Solver CADET-CS
(2012)

Master Thesis

Minimalgenom - Bedeutung der Corynebacterium-Prophagen für die Fitness von Corynebacterium glutamicum
(2012)

Master Thesis

Bioprozessentwicklung zur anaeroben Produktion von Succinat in C. glutamicum
(2012)

Master Thesis

Prevention of Bacterial Cell Adhesion for Microfluidic Single-Cell-Analysis
(2012)

Bachelor Thesis

13C-Metabolomanalyse von Gluconobacter oxydans im parallelen Kleinkultursystem
66 p. (2012)

Beiträge in Büchern 2012

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Acyloin and Benzoin Condensations
Enzyme Catalysis in Organic Synthesis, Drauz, K.; Gröger, H.; May, O., Third Edition, Weinheim, Wiley-VCH, 2012, 919-945 (2012)

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Direct Analysis of Underivatized Amino Acids in Plant Extracts by LC-MS-MS
Amino Acid Analysis: Methods and Protocols, Alterman, M.A. and Hunziker, P., Methods in Molecular Biology, Springer Science+Business Media, Humana Press, 2012, Methods in Molecular Biology Vol. 828, 978-1-61779-444-5, 317-328 (2012) [10.1007/978-1-61779-445-2]  GO


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