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Institute of Bio- and Geosciences

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Research topics



Biocatalysis

We investigate and optimize enzymes and biocatalytic processes for the production of preferably chiral fine chemicals. Therefore we use an integrated engineering approach to tailor enzymes and reactions systems for a desired reaction. We create enzyme toolboxes with the following enzyme classes:

·          Lyases (e.g. Thiamine-diphosphate dependent enzymes, hydroxyl­nitrile lyases)

·          Oxidoreductases (e.g. alcohol dehydrogenases and enoate reductases)

·          Transferases (e.g. transaminases)

·          Racemases (e.g. amino acid racemases)

The Helmholtz-young investigator group `Synthetic enzyme cascades´ from Dörte Rother investigates strategies for the smart combination of enzymes from enzyme toolboxes. Besides multi-step syntheses with purified enzymes, the potential of synthetic enzyme cascades using whole cell biocatalysts in aqueous as well as in non-conventional media is investigated. Especially the development of ecoefficient process strategies combining high productivity with high atom- and step economy are in focus of the young investigator team.


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Biosensors

 

We develop genetically encoded biosensors for the quantitative metabolite analysis.

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