93. 1. Ramin, E.; Gaetano Cardillo, A.; Liebers, R.; Schmölder, J.; von Lieres, E.; van Molle, W.; Niebel, B.; Natalis, L.; Meln, I.; Perea-Vélez, M.; Clénet, D.; Bagterp Jørgensen, J.; Nilsson, B.; Bracewell, D.; Gernaey, K.: Accelerating vaccine manufacturing development through model-based approaches: Current advances and future opportunities, Current Opinion in Chemical Engineering 43 (2024): 100998.
92. Heymann, W.; Glaser, J.; Schlegel, F.; Johnson, W.; Rolandi, P.; von Lieres. E.: Advanced error modeling and Bayesian uncertainty quantification in mechanistic chromatography modeling, Journal of Chromatography A 1708 (2023): 464329.
91. Rao, J.; Püttmann, A.; Khirevich, S.; Tallarek, U.; Geuzaine, C.; Behr, M.; von Lieres, E.: High definition simulation of packed bed chromatography, Computers and Chemical Engineering 178 (2023): 108355.
90. Breuer, J.; Leweke, S.; Schmölder, J.; Gassner, G.; von Lieres, E.: Spatial discontinuous Galerkin spectral element method for a family of chromatography models in CADET, Computers and Chemical Engineering 177 (2023): 108340.
89. Helleckes, L.; Hemmerich, J.; Wiechert, W.; von Lieres, E.; Grünberger, A.: Machine learning in bioprocess development: From promise to practice, Trends in Biotechnology 41,6 (2023): 817-835.
88. Schmitz, J.; Stute, B.; Täuber, S.; Kohlheyer, D.; von Lieres, E.; Grünberger, A.: Reliable cell retention of mammalian suspension cells in micro-fluidic cultivation chambers, Scientific Reports 13 (2023): 3857.
87. Siedentop, R.; Siska, M.; Möller, N.; Lanzrath, H.; von Lieres, E.; Lütz, S.; Rosenthal, K.: Bayesian optimization for an ATP regenerating in vitro enzyme cascade, MDPI Catalysts, 13 (2023): 468.
86. Stephan, M.; Stute, B.; von Lieres, E.; Müller, T.: Consecutive three-component synthesis of phenothiazine based merocyanines – Bayesian optimization, electronic properties, and DSSC characteristics, European Journal of Organic Chemistry 29 (2022), e202200163.
85. Kondrat, S.; Krauss, U.; von Lieres, E.: Enzyme co-localisation: Mechanisms and benefits, Current Research in Chemical Biology 2 (2022): 100031.
84. Kuppe, C.; Schnepf, A.; von Lieres, E.; Watt, M.; Postma, J.: Rhizosphere models: Their concepts and application to plant-soil ecosystems, Plant and Soil 474 (2022), 17–55.
83. Ho, P.; Täuber, S.; Stute, B.; Grünberger, A.; von Lieres, E.: Microfluidic reproduction of dynamic bioreactor environment based on computational lifelines, Frontiers in Chemical Engineering 4 (2022): 826485.
82. Helleckes, L.; Osthege, M.; Wiechert, W.; von Lieres, E.; Oldiges, M.: Bayesian calibration, process modeling and uncertainty quantification in biotechnology, PLOS Computational Biology 18,3 (2022): e1009223.
81. Heymann, W.; Glaser, J.; Schlegel, F.; Johnson, W.; Rolandi, P.; von Lieres, E.: Advanced score system and automated search strategies for parameter estimation in mechanistic chromatography modeling, Journal of Chromatography A 1661 (2022): 462693.
80. Oeggl, R.; Diedrich, J.; von Lieres, E.; Rother, D.: Continuous enzymatic stirred tank reactor cascade with unconventional medium yielding high concentrations of (S)-2-hydroxyphenyl propanone and its derivatives, Catalysis Science and Technology 11 (2021), 7886–7897.
79. Kumar, V.; Leweke, S.; Heymann, W.; von Lieres, E.; Schlegel, F.; Westerberg, K.; Lenhoff, A.: Robust mechanistic modeling of protein ion-exchange chromatography using a colloidal isotherm, Journal of Chromatography A 1660 (2021): 462669.
78. Loomba, V.; von Lieres, E.; Huber, G.: How do operational and design parameters effect biomass productivity in a flat-panel photo-bioreactor? A computational analysis, MDPI Processes 9,8 (2021): 1387.
77. Beck, J.; von Lieres, E.; Zaghi, N.; Leweke, S.; Carta, G.; Hahn, R.: Patterns of protein adsorption in ion-exchange particles and columns: Evolution of protein concentration profiles during load, hold, and wash steps predicted for pore and solid diffusion mechanisms, Journal of Chromatography A 1653 (2021): 462412.
76. Dippel, J.; Handt, S.; Stute, B.; von Lieres, E.; Loewe, T.: Fluid dynamics in pleated membrane filter devices, Separation & Purification Technology 267 (2021) 118580.
75. Chernomor, O.; Peters, L.; Schneidewind, J.; Loeschcke, A.; Knieps-Grünhagen, E.; Schmitz, F.; von Lieres, E.; Kutta, R.; Svensson, V.; Jäger, K.-E.; Drepper, T.; von Haeseler, A.; Krauss, U.: Complex evolution of light-dependent protochlorophyllide oxidreductases in aerobic anoxygenic phototrophs: origin, phylogeny and function, Molecular Biology and Evolution 38,3 (2021): 819–837.
74. Schmitz, J.; Täuber, S.; Westerwalbesloh, C.; von Lieres, E.; Noll, T.; Grünberger, A.: Development and application of a cultivation platform for mammalian suspension cell lines with single-cell resolution, Biotechnology and Bioengineering 118,2 (2021): 992–1005.
73. Roush, D.; Asthagiri, D.; Babi, D.; Benner, S.; Bilodeau, C.; Carta, G.; Ernst, P.; Fedesco, M.; Fitzgibbon, S.; Flamm, M.; Hansen, E.; Hahn, T.; Hunt, S.; Insaidoo, F.; Lenhoff, A.; Lin, J.; Marke, H.; Marques, B.; Papadakis, E.; Popp, O.; Rolandi, P.; Schlegel, F.; Smith, B.; Staby, A; Stenevang,M.; Sun, L.; Tessier, P.; von Lieres, E.; Welsh, J.; Willson, R.; Wang, G.; Wucherpfennig, T.; Zavalov, O.: Toward in silico CMC: An industrial collaborative approach to model-based process development, Biotechnology and Bioengineering 117,12 (2020): 3986–4000.
72. Täuber, S.; Golze, C.; Ho, P.; von Lieres, E.; Grünberger, A: dMSCC: A microfluidic platform for microbial single-cell cultivation under dynamic environmental medium conditions, Lab on a Chip 20 (2020): 4442–4455.
71. Zhao, X.; Ploch, T.; Noack, S.; Wiechert, W.; Mitsos, A.; von Lieres, E.: Analysis of the local well-posedness of optimization-constrained differential equations by local optimality conditions, AIChE Journal 66,10 (2020), e16548.
70. Meyer, K.; Leweke, S.; von Lieres, E.; Huusom, J.; Abildskov, J.: ChromaTech: A discontinuous Galerkin spectral element simulator for preparative liquid chromatography, Computers and Chemical Engineering 141 (2020), 107012.
69. Beck, J.; Heymann, W.; von Lieres, E.; Hahn, R.: Compartment model of mixing in a bubble trap and its impact on chromatographic separations, Processes 8,7 (2020): 780.
68. Ploch, T.; von Lieres, E.; Wiechert, W.; Mitsos, A.; Hannemann-Tamás, R.: Simulation of differential-algebraic equation systems with optimization criteria embedded in Modelica, Computers and Chemical Engineering 140 (2020): 106920.
67. Velali, E.; Dippel, J.; Stute, B.; Handt, S.; Löwe, T.; von Lieres, E.: Model-based performance analysis of pleated filters with non-woven layers, Separation & Purification Technology 250 (2020), 117006.
66. He, Q.-L.; von Lieres, E.; Zhao, L.; Sun, Z.: Model-based process design of a ternary protein separation using multi-step gradient ion-exchange SMB chromatography, Computers and Chemical Engineering 138 (2020): 106851.
65. Täuber, S.; von Lieres, E.; Grünberger, A.: Dynamic environmental control in microfluidic single-cell cultivations: From concepts to applications, Small (2020): 1906670.
64. Ploch, T.; Zhao, X.; Hüser, J.; von Lieres, E.; Hannemann-Tamás, R.; Naumann, U.; Wiechert, W.; Mitsos, A.; Noack, S.: Multi-scale dynamic modeling and simulation of a biorefinery, Biotechnology and Bioengineering 116,10 (2019): 2561–2574.
63. Poonoosamy, J.; Westerwalbesloh, C.; Deissmann, G.; Mahrous, M.; Curti, E.; Churakov, S.; Klinkenberg, M.; Kohlheyer, D.; von Lieres, E.; Bosbach, D.; Prasianakis, N.:A microfluidic experiment and complementary pore scale modelling diagnostics for assessing mineral precipitation and dissolution in confined spaces, Chemical Geology 528 (2019): 1198264.
62. Lindemann, D.; Westerwalbesloh, C.; Kohlheyer, D.; Grünberger, A.; von Lieres, E.: Microbial single-cell growth response at defined carbon limiting growth conditions, RSC Advances 9 (2019): 14040–14050.
61. Ho, P.; Westerwalbesloh, C.; Kaganovitch, E.; Grünberger, A.; Neubauer, P.; Kohlheyer, D.; von Lieres, E.: Reproduction of large-scale bioreactor conditions on microfluidic chips, Microorganisms 7,4 (2019): 105.
60. Kuzmak, A.; Carmali, S.; von Lieres, E.; Russell, A.; Kondrat, S.: Can enzyme proximity accelerate cascade reactions?, Scientific Reports 9 (2019): 455.
59. Burmeister, A.; Hilgers, F.; Langner, A.; Westerwalbesloh, C.; Kerkhoff, Y.; Tenhaef, N.; Drepper, T.; Kohlheyer, D.; von Lieres, E.; Noack, S.; Grünberger, A.: A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments, Lab on a Chip 19 (2019): 98–110.
58. Velali, E.; Stute, B.; Leuthold, M.; von Lieres, E.: Model-based performance analysis and scale-up of membrane adsorbers with a cassettes format designed for parallel operation, Chemical Engineering Science 192 (2018), 103–113.
57. Bühler, J.; von Lieres, E.; Huber, G.: Model based design of long distance tracer transport experiments in plants, Frontiers in Plant Science 9 (2018), 773.
56. Loomba, V.; Huber, G.; von Lieres, E.: Single-cell computational analysis of light harvesting in a flat-panel photo-bioreactor, Biotechnology for Biofuels 11 (2018), 149.
55. Leweke, S.; von Lieres, E.: Chromatography Analysis and Design Toolkit (CADET), Computers and Chemical Engineering 113 (2018), 274–294.
54. He, Q.-L.; Leweke, S.; von Lieres, E.: Efficient numerical simulation of simulated moving bed chromatography with a single-column solver, Computers and Chemical Engineering 111 (2018), 183–198.
53. Freier, L.; von Lieres, E.: Robust multi-objective global optimization of stochastic processes with a case study in gradient elution chromatography, Biotechnology Journal 13,1 (2018), 1700257.
52. Morschett, H.; Lomba, V.; Huber, G.; Wiechert, W.; von Lieres, E.; Oldiges, M.: Laboratory scale photobiotechnology – Current trends and future perspectives, FEMS Microbiology Letters 365,1 (2018), fnx238.
51. Hemmerich, J.; Freier, L.; Wiechert, W.; von Lieres, E.; Oldiges, M.: Generic protocol for optimization of heterologous protein production using automated microbioreactor technology, Journal of Visualized Experiments 230 (2017), e56234.
50. Diedrich, J.; Heymann, W.; Leweke, S.; Kunert, C.; Johnson, W.; Hunt, S.; Todd, B.; von Lieres, E.: Multi-state steric mass-action model and case study on complex high loading behavior of mAb on ion exchange tentacle resin, Journal of Chromatography A 1525 (2017), 60–70.
49. Zhao, X.; Noack, S.; Wiechert, W.; von Lieres, E.: Dynamic flux balance analysis with nonlinear objective function, Journal of Mathematical Biology 75,6 (2017), 1487–1515.
48. Freier, L.; Wiechert, W.; von Lieres, E.: Kriging with trend functions nonlinear in their parameters: Theory and application in enzyme kinetics, Engineering in Life Sciences 17,8 (2017), 916–922.
47. Freier, L.; von Lieres, E.: Multi-objective global optimization (MOGO): Algorithm and case study in gradient elution chromatography, Biotechnology Journal 12,7 (2017), 1600613.
46. Westerwalbesloh, C.; Grünberger, A.; Wiechert, W.; Kohlheyer, D.; von Lieres, E.: Coarse graining bacteria colonies for modeling critical solute distributions in pico-liter bioreactors for bacterial studies on single-cell level, Microbial Biotechnology 10,4 (2017), 845–857.
45. Bühler, J.; Huber, G.; von Lieres, E.: Finite volume schemes for the numerical simulation of tracer transport in plants, Mathematical Biosciences 288 (2017), 14–20.
44. Morschett, H.; Freier, L.; Rohde, J.; Wiechert, W.; von Lieres, E.; Oldiges, M.: A framework for accelerated phototrophic bioprocess development: Integration of parallelized microscale cultivation, laboratory automation and Kriging-assisted experimental design, Biotechnology for Biofuels 10,26 (2017), 1–13.
43. Poshyvailo, L.; von Lieres, E.; Kondrat, S.: Does metabolite channeling accelerate enzyme-catalyzed cascade reactions?, PLOS ONE 12,2 (2017), 1–17.
42. Kiefer, J.; Wei, G.; Ciacchi, L. C.; von Lieres, E.: Irreversible damage of polymer membranes during attenuated total reflection infrared analysis, Applied Spectroscopy 71,6 (2017), 1127–1133.
41. Freier, L.; Hemmerich, J.; Schöler, K.; Wiechert, W.; Oldiges, M.; von Lieres, E.: Framework for Kriging based iterative experimental analysis and design: Optimization of secretory protein production in Corynebacterium glutamicum, Engineering in Life Sciences 16 (2016): 538–549.
40. Jussen, D.; Soltner, H.; Stute, B.; Wiechert, W.; von Lieres, E.; Pohl, M.: µMORE: A microfluidic magnetic oscillation reactor for accelerated parameter optimization in biocatalysis, Journal of Biotechnology 231 (2016), 174–182.
39. Kondrat, S.; Zimmermann, O.; Wiechert, W.; von Lieres, E.: Discrete-Continuous reaction-diffusion model with mobile point-like sources and sinks, European Physical Journal E 39,11 (2016), 1–10.
38. Püttmann, A.; Schnittert, S.; Leweke, S.; von Lieres, E.: Utilizing algorithmic differentiation to efficiently compute chromatograms and parameter sensitivities, Chemical Engineering Science 139 (2016), 152–162.
37. Leweke, S.; von Lieres, E.: Fast arbitrary order moments and arbitrary precision solution of the general rate model of column liquid chromatography with linear isotherm, Computers and Chemical Engineering 84 (2016), 350–362.
36. Kumar, V.; Leweke, S.; von Lieres, E.; Rathore, A.: Mechanistic modeling of ion-exchange process chromatography of charge variants of monoclonal antibody products, Journal of Chromatography A 1426 (2015), 140–153.
35. Grünberger, A.; Probst, C.; Helfrich, S.; Nanda, A.; Stute, B.; Wiechert, W.; von Lieres, E.; Nöh, K.; Frunzke, J.; Kohlheyer, D.: Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform, Cytometry A 87,12 (2015), 1101–1115.
34. Westerwalbesloh, C.; Grünberger, A.; Stute, B.; Weber, S.; Wiechert, W.; Kohlheyer, D.; von Lieres, E.: Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level, Lab on Chip 15 (2015), 4177–4186.
33. Kondrat, S.; Zimmermann, O.; Wiechert, W.; von Lieres, E.: The effect of composition on diffusion of macromolecules in crowded environment, Physical Biology 12 (2015), 046003.
32. Ghosh, P.; Lin, M.; Vogel, J. H.; Choy, D.; Haynes, C.; von Lieres E.: Zonal rate model for axial and radial flow membrane chromatography, part II: Model based scale-up, Biotechnology and Bioengineering 111,8 (2014), 1587–1594.
31. Püttmann, A.; Nicolai, M.; Behr, M.; von Lieres, E.: Stabilized space-time finite elements for high-definition simulation of packed bed chromatography, Finite Elements in Analysis and Design 86 (2014), 1–11.
30. Choy, D.; Creagh, L.; von Lieres, E.; Haynes, C.: A new mixed-mode model for interpreting and predicting protein elution during isoelectric chromatofocusing, Biotechnology and Bioengineering 111,5 (2014), 925–936.
29. Ghosh, P.; Vahedipour, K.; Leuthold, M.; von Lieres, E.: Model-based analysis and quantitative prediction of membrane chromatography: Extreme scale-up from 0.08 ml to 1200 ml, Journal of Chromatography A 1332 (2014), 8–13.
28. Baraibar, Á.; von Lieres, E.; Wiechert, W.; Pohl, M.; Rother, D.: Effective production of (S)-α-hydroxy ketones: A reaction engineering approach, Topics in Catalysis 57,5 (2014), 401–411.
27. Kiefer, J.; Rasul, N. H.; Ghosh, P. K.; von Lieres, E.: Surface and bulk porosity mapping of polymer membranes using infrared spectroscopy, Journal of Membrane Science 452 (2014), 152–156.
26. Bühler, J.; von Lieres, E.; Huber, G.: A family of compartmental models for long-distance tracer transport in plants, Journal of Theoretical Biology 341 (2014), 131–142.
25. Ghosh, P.; Vahedipour, K.; Lin, M.; Vogel, J. H.; Haynes, C.; von Lieres, E: Computational fluid dynamic simulation of axial and radial flow membrane chromatography: Mechanisms of non-ideality and validation of the zonal rate model, Journal of Chromatography A 1305 (2013), 114–122.
24. Sehl, T.; Hailes, H. C.; Ward, J. M.; Wardenga, R.; von Lieres, E.; Offermann, H.; Westphal, R.; Pohl, M.; Rother, D.: Two steps in one pot: Enzyme cascade for the synthesis of nor(pseudo)ephedrine from inexpensive starting materials, Angewandte Chemie International Edition 52,26 (2013), 6772–6775.
23. Püttmann, A.; Schnittert, S.; Naumann, U.; von Lieres, E.: Fast and accurate parameter sensitivities for the general rate model of column liquid chromatography, Computers and Chemical Engineering 56 (2013), 46–57.
22. Borg, N.; Westerberg, K.; Andersson, N.; von Lieres, E.; Nilsson, B.: Effects of uncertainties in experimental conditions on the estimation of adsorption model parameters in preparative chromatography, Computers and Chemical Engineering 55 (2013), 148–157.
21. Stute, B.; Krupp, V.; von Lieres, E.: Performance of iterative equation solvers for mass transfer problems in three-dimensional sphere packings in COMSOL, Simulation Modelling Practice and Theory 33 (2013), 115–131.
20. Ghosh, P.; Vahedipour, K.; Lin, M.; Vogel, J. H.; Haynes, C.; von Lieres, E.: Zonal rate model for axial and radial flow membrane chromatography, part I: Knowledge transfer across operating conditions and scales, Biotechnology and Bioengineering 110,4 (2013), 1129–1141.
19. Gerhards, T.; Mackfeld, U.; von Lieres, E.; Wiechert, W.; Pohl, M.; Rother, D.: Influence of organic solvents on enzymatic asymmetric carboligations, Advanced Synthesis & Catalysis 354,14-15 (2012), 2805–2820.
18. Winz, R.; Wiechert, W.; von Lieres, E.: Surface bound adsorption in a microfluidic T-sensor: Numerical comparison and optimization of 2D and 3D models and of sensor designs, Sensors and Actuators B: Chemical 170 (2012), 75–81.
17. Osberghaus, A.; Baumann, P.; Hepbildikler, S.; Nath, S.; Haindl, M.; von Lieres, E.; Hubbuch, J.: Detection, quantification, and propagation of uncertainty in high throughput experimentation by Monte Carlo methods, Chemical Engineering and Technology 35,8 (2012), 1456–1464.
16. Osberghaus, A.; Drechsel, K.; Hansen, S.; Hepbildikler, S.; Nath, S.; Haindl, M.; von Lieres, E.; Hubbuch, J.: Model-integrated process development demonstrated on the optimization of a robotic cation exchange step, Chemical Engineering Science 76 (2012), 129–139.
15. Osberghaus, A.; Hepbildikler, S.; Nath, S.; Haindl, M.; von Lieres, E.; Hubbuch, J.: Optimizing a chromatographic three component separation: A comparison of mechanistic and empiric modeling approaches, Journal of Chromatography A 1237 (2012), 86–95.
14. Osberghaus, A.; Hepbildikler, S.; Nath, S.; Haindl, M.; von Lieres, E.; Hubbuch, J.: Determination of parameters for the steric mass action model – A comparison between two approaches, Journal of Chromatography A 1233 (2012), 54–65.
13. Francis, P.; von Lieres, E.; Haynes, C.: Zonal rate model for stacked membrane chromatography: II. Characterizing ion-exchange membrane chromatography under protein retention conditions, Biotechnology and Bioengineering 109,3 (2012), 615–629.
12. Francis, P.; von Lieres, E.; Haynes, C.: Zonal rate model for stacked membrane chromatography: I. Characterizing solute dispersion under flow-through conditions, Journal of Chromatography A 1218,31 (2011), 5071–5078.
11. von Lieres, E.; Andersson, J.: A fast and accurate solver for the general rate model of column liquid chromatography, Computers and Chemical Engineering 34,8 (2010), 1180–1191.
10. von Lieres, E.; Wang, J.; Ulbricht, M.: Model based quantification of internal flow distributions from breakthrough curves of flat sheet membrane chromatography modules, Chemical Engineering and Technology 33,6 (2010), 960–968.
9. Siudak, A.; von Lieres, E.; Müller, C. H.: Estimation, model discrimination, and experimental design for implicitly given nonlinear models of enzyme catalyzed chemical reactions, Mathematica Slovaca 59,5 (2009), 593–610.
8. Susanto, A.; Knieps-Grünhagen, E.; von Lieres, E.; Hubbuch, J.:High throughput screening for the design and optimization of chromatographic processes: Automated optimization of chromatographic phase systems, Chemical Engineering and Technology 32,1 (2009), 140–154.
7. Susanto, A.; Knieps-Grünhagen, E.; von Lieres, E.; Hubbuch, J.:High throughput screening for the design and optimization of chromatographic processes: Assessment of model parameter determination from high throughput compatible data, Chemical Engineering and Technology 31,12 (2008), 1846–1855.
6. von Lieres, E.; Frauen, C.; Nöh, K.: Fast solution of chromatographic particle and column models on parallel computers, International Journal of Pure and Applied Mathematics 42,3 (2008), 309–317.
5. Susanto, A.; Herrmann, T.; von Lieres, E.; Hubbuch, J.: Investigation of pore diffusion hindrance of monoclonal antibody in hydrophobic interaction chromatography using confocal laser scanning microscopy, Journal of Chromatography A 1149,2 (2007), 178–188.
4. Teske, C.; von Lieres, E.; Schröder, M.; Ladiwala, A.; Cramer, S. M.; Hubbuch, J.: Competitive adsorption of labeled and native protein in confocal laser scanning microscopy, Biotechnology and Bioengineering 95,1 (2006), 58–66.
3. Schröder, M.; von Lieres, E.; Hubbuch, J.: Direct quantification of intraparticle protein diffusion in chromatographic media, Journal of Physical Chemistry B 110,3 (2006), 1429–1436.
2. Bensch, M.; Schulze Wierling, P.; von Lieres, E.; Hubbuch, J.: High throughput screening of chromatographic phases for rapid process development, Chemical Engineering and Technology 28,11 (2005), 1274–1284.
1. Knosowski, Y.; von Lieres, E.; Schneider, A.: Regularization of a non-characteristic Cauchy-problem for a parabolic equation in multiple dimensions, Inverse Problems 15,3 (1999), 731–743.
