Regulatory Switches and Synthetic Biology Group
Dr. Tino Polen
Institute of Biotechnology 1
Forschungszentrum Jülich GmbH
52425 Jülich
Germany
Phone:
+49 (2461) 61-6205
Fax:
+49 (2461) 61-2710
E-Mail:
t.polen@fz-juelich.de
Group members
Alumni
Research
Regulatory mechanisms allow for adaptation of living cells not only to a changing environment, but also to intracellular states. In the fields of Metabolic Engineering and Synthetic Biology, detailed knowledge of the host’s regulatory mechanisms is pivotal for rational strain development.
Synthetic biology can be considered as "... the design and construction of new biological components, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. Synthetic biology builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components (parts of enzymes, genetic circuits, metabolic pathways, etc.) that can be modeled, understood, and tuned to meet specific performance criteria, and the assembly of these smaller components into larger integrated systems that solve specific problems." (Taken from Keasling, JD; ACS Chem. Biol. 2008; 3 (1): 64–76)
Our research on global regulation and on Metabolic Engineering of Corynebacterium glutamicum and Escherichia coli focuses on the production of amino acids, other primary metabolites as well as new products and thus belongs to the field of
White Biotechnology 
.
last change 28.06.2010 | IBT Webmaster | Print
|
| Our group in June 2010 |
Institute of Biotechnology 1
Forschungszentrum Jülich GmbH
52425 Jülich
Germany
Phone:
+49 (2461) 61-6205
Fax:
+49 (2461) 61-2710
E-Mail:
t.polen@fz-juelich.de
Group members AlumniResearch
Regulatory mechanisms allow for adaptation of living cells not only to a changing environment, but also to intracellular states. In the fields of Metabolic Engineering and Synthetic Biology, detailed knowledge of the host’s regulatory mechanisms is pivotal for rational strain development.
Synthetic biology can be considered as "... the design and construction of new biological components, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. Synthetic biology builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components (parts of enzymes, genetic circuits, metabolic pathways, etc.) that can be modeled, understood, and tuned to meet specific performance criteria, and the assembly of these smaller components into larger integrated systems that solve specific problems." (Taken from Keasling, JD; ACS Chem. Biol. 2008; 3 (1): 64–76)
Our research on global regulation and on Metabolic Engineering of Corynebacterium glutamicum and Escherichia coli focuses on the production of amino acids, other primary metabolites as well as new products and thus belongs to the field of
White Biotechnology .
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last change 28.06.2010 | IBT Webmaster | Print