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Zelluläre Biophysik (ICS-4)
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Novel therapeutic options for human diseases

In the human disease retinitis pigmentosa the photoreceptors degenerate, leading to blindness. Electrical prostheses can elicit visual sensations in patients; however, processes secondary to photoreceptor death lead to pathological rhythmic activity in the remaining retinal network that seems to interfere with this therapeutic approach. We study and characterize signal transmission in both healthy and diseased mouse retina and, in co-operation with partners from universities and from within the Forschungszentrum, aim at developing improved prosthetic devices.

  1. Müller, F., Scholten, A., Ivanova, E., Haverkamp, S., Kremmer, E., und Kaupp, U.B. (2003): HCN channels are differentially expressed in retinal bipolar cells and concentrated at synaptic terminals. European Journal of Neuroscience 17: 2084-2096.
  2. Mataruga, A., Kremmer, E. und Müller, F. (2007): Type 3a and 3b OFF-cone bipolar cells provide for the alternative rod pathway in the mouse retina. Journal of Comparative Neurology 502: 1123-1137.
  3. Knop, G., Seeliger, M.W., Thiel, F., Mataruga, A., Kaupp, U.B., Friedburg, C., Tanimoto, N, und Müller, F. (2008): Light responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene. European Journal of Neurosience 28:2221-2230
  4. Wässle, H., Puller, C., Müller, F. und Haverkamp, S. (2009): Cone contacts, mosaics, and territories of bipolar cells in the mouse retina. Journal of Neuroscience 29: 106-117.
  5. Seeliger, M.W., Brombas, A., Weiler, R., Humphries, P., Knop, G., Tanimoto, N., and Müller, F. (2012): Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision. Nature Communications 2:532/DOI:10.1038/ncomms1540
  6. Biswas S, Haselier C, Mataruga A, Thumann G, Walter P, Müller F. Pharmacological analysis of intrinsic neuronal oscillations in rd10 retina. PloS one. 2014;9(6):e99075. doi: 10.1371/journal.pone.0099075. PubMed PMID: 24918437; PubMed Central PMCID: PMC4053359.
  7. Rösch S, Johnen S, Mataruga A, Müller F, Pfarrer C, Walter P. Selective photoreceptor degeneration by intravitreal injection of N-methyl-N-nitrosourea. Investigative ophthalmology & visual science. 2014;55(3):1711-23. doi: 10.1167/iovs.13-13242. PubMed PMID: 24550357.

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