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Cell Engineering

By introducing and specifically targeting new proteins into cells, we aim to create systems that allow us to probe information processing in cell networks and generate new bioelectronic materials. Our current research is focused on:

Optogenetic Actuators

Optogenetic Actuators

Stimulation and inhibition of neuronal signaling using light actuated channels and pumps. Optogenetic actuators based on Channelrhodopsin, Halorhodopsin, and Photactivated adenyl cyclase are employed.

Genetically Encoded Voltage Indicators

Genetically Encoded Voltage Indicators

The membrane potential of the cell is monitored fluorescently using membrane associated proteins. Voltage changes are detected based on FRET or quenching of the inserted fluorophore.

Team

Timm Hondrich

Timm Hondrich, Doctoral Researcher

email: t.hondrich@fz-juelich.de
tel: +49 (0)2461 61 3542
Research activities: optogenetics, patterned neural networks, microcontact printing, electrophysiology

Vanessa Maybeck

Dr. Vanessa Maybeck, PI

email:  v.maybeck@fz-juelich.de
tel: +49 (0)2461 61 3285
Research activities: Engineered bioelectronic materials

Sarah Roßbiegalle

Sarah Roßbiegalle, Bachelor Student

email:  s.rossbiegalle@fz-juelich.de
tel: +49 (0)2461 61 2466
Research activities: molecular biology, genetic engineering

Irina Tihaa

Irina Tihaa, Doctoral Researcher

email:   i.tihaa@fz-juelich.de
tel: +49 (0)2461 61 2357
Research activities: Patterned optogenetic networks

Former Members

Wenfang Li, Doctoral researcher until 03/2017
Lei Jin, Doctoral Researcher until 07/2016

Additional Information

Contact:

Dr. Vanessa Maybeck

Tel.:  +49-2461-61-3285
e-mail: v.maybeck@fz-juelich.de

Recent Publications

Jin L, LangeW, Kempmann A, Maybeck V,Günther A, Gruteser N, etal. High-efficiency transduction andspecific expression of ChR2optfor optogenetic manipulation ofprimary cortical neurons mediatedby recombinant adeno-associated viruses.J Biotechnol 2016; 233:171–80.
https://doi.org/10.1016/j.jbiotec.2016.07.001

Maybeck V, SchnitkerJ, Li W, Heuschkel M,Offenhäusser A. An evaluation ofextracellular MEA versus optogeneticstimulation of cortical neurons.Biomed Phys Eng Express2016; 2:055017. https://doi.org/10.1088/2057-1976/2/5/055017



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