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Logic Gate: Combine Aptamer-Based Biorecognition with Molecular-Level Bioelectronics

Yes or no? A novel split aptamer-based multi-level logic gate, which is built from INHIBIT and AND gates, performs a net XOR analysis, with an electrochemical signal as output. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operations and which simplify an otherwise complex diagnosis to a yes/no decision.

Multi-Level Logic Gate Operation Based on Amplified Aptasensor Performance

Lingyan Feng, Zhaozi Lyu, Andreas Offenhäusser, and Dirk Mayer

Appeared in: Angew. Chem. Int. Ed. 2015, 54, 7693 –7697

DOI: 10.1002/anie.201502315 

 

Logic GateSchematic illustration of the aptamer-based biosensor design and its multi-level INH-AND-XOR logic gate. Taking ATP split aptamer as molecular recognition motif, several (bio)chemical input signals can be converted into one output signal, which reports on the overall status of the system.

Abstract: Conventional electronic circuits can perform multilevel logic operations; however, this capability is rarely realized by biological logic gates. In addition, the question of how to close the gap between biomolecular computation and siliconbased electrical circuitry is still a key issue in the bioelectronics field. Here we explore a novel split aptamer-based multi-level logic gate built from INHIBIT and AND gates that performs a net XOR analysis, with electrochemical signal as output. Based on the aptamer–target interaction and a novel concept of electrochemical rectification, a relayed charge transfer occurs upon target binding between aptamer-linked redox probes and solution-phase probes, which amplifies the sensor signal and facilitates a straightforward and reliable diagnosis. This work reveals a new route for the design of bioelectronic logic circuits that can realize multi-level logic operation, which has the potential to simplify an otherwise complex diagnosis to a “yes” or “no” decision.

http://onlinelibrary.wiley.com/doi/10.1002/anie.201502315/pdf


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