Neurofilament light chain (NfL) is an important blood-based biomarker of neuroaxonal damage and holds strong potential for the early detection and monitoring of neurodegenerative diseases. However, its extremely low abundance in blood poses a major analytical challenge for sensitive and reliable detection.

we propose a novel impedance-based model incorporating both capacitive coupling and resistive voltage division across the electrolyte to explain these effects. Our model successfully predicts and verifies a frequency-dependent threshold voltage shift under high-frequency signals.

Self-powered electrochemical sensors have the potential to advance the field of electrochemical sensors by providing energy and material savings, using the two-electrode galvanic cell principle instead of the three-electrode cell method employed by potentiostatically controlled methods. Our article „Selection of Anode Half-Cells for Hydrogen Peroxide Self-Powered Electrochemical Sensors Using Biomimetic Metal Complex Cathode Catalysts” provides novel insights into the operation mechanism of the self-powered electrochemical sensors for the determination of hydrogen peroxide.