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Institute of Neuroscience and Medicine

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MRI Spectroscopy

The aim of this project is to produce brain metabolites concentration (coloured) maps. An example can be seen on Fig.2, showing a map of the concentration ratio between the Creatine (Cr) and the N-Acetyl-Aspartate (NAA) in a tumour-bearing patient.

MR SpectrumFig.1 Spectrum measured out of one voxel.

Spectroscopy is a very sensitive MRI technique, a large panel of artefacts can corrupt the measured spectrum. But this technique can also provide really interesting information such as the concentrations of relevant chemicals (e.g. neurotransmitters) in the brain.

NAA ConcentrationFig. 2 Example of a brain metabolites concentration map made thanks to the SIEMENS spectroscopy toolbox available on the scanner console.

This example was made thanks to the SIEMENS spectroscopy toolbox available on the scanner console. Such maps can be improved, but to be able to produce such maps a proper MRI sequence has to be developed with all the complications that a sequence development involves.

The second step consists in computing from the measured spectrum the concentration of every metabolite of interest constituting this spectrum (Fig.1). Several algorithms already exist and could be implemented and/or improved. The output of such algorithms is a table stating the computed metabolites concentrations present in the voxels.

The last step is to transform this table into a coloured map.


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