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6-[18F]Fluoro-L-Dopa

A new efficent synthesis of 6-[18F]fluoro-L-dopa allows a broad application of this important radiopharmaceutical.

In 2009 the INM-5 presented a novelnucleophilic pathway to 6-[18F]fluoro-L-DOPA synthesis that is not only more efficient than hitherto known methods, but it is also capable of being up-scaled in existing automated synthesizer modules offering a reliable large scale production method of 6-[18F]fluoro-L-DOPA. The synthesis was published in Journal of Nuclear Medicine (F. M. Wagner, J. Ermert, H. H. Coenen, J. Nucl. Med., 2009, 50, 1724-1729).


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