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Radiotracer development

A prerequisite for the syntheses of radiotracers for the positron emission tomography is the development of new methods for the introduction of the very low amounts (<10-9 g) of a positron emitter (e.g. fluorine-18, carbon-11) into organic molecules in a short time scale.

PDB 2YDO THERMOSTABILISED HUMAN A2A RECEPTOR WITH ADENOSINE BOUND

The main focus is on the development of syntheses of new 18F-fluorinated amino acids, which will be used for the diagnosis of brain tumors and neurodegenerative diseases. A further focus is on the development of new 11C- and 18F-labelled ligands of the dopaminergic and serotonergic receptor system. For these entire fields novel labeling strategies will be developed which even enables the synthesis of the corresponding compounds.

PDB 2YDO THERMOSTABILISED HUMAN A2A RECEPTOR WITH ADENOSINE BOUND

A further area of activity is the improvement of technologies for the syntheses of radiopharmaceuticals with regard to a better automation and product quality.

Additional Information

Group Leaders

Dr. Marcus Holschbach

Building: 15.19, Room: 2025
Tel.:  +49-2461-61-6961
E-Mail: m.holschbach@fz-juelich.de


Prof. Dr. Johannes Ermert

Building: 15.19, Room: 4009
Tel.:  +49-2461-61-3110
E-Mail: j.ermert@fz-juelich.de


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