Highlights


Surface-FIDA a new diagnostic tool for prion diseases and other protein misfolding diseases

A characteristic feature of prion diseases like bovine spongiform encephalopathy (BSE) is the accumulation of a pathological isoform of the host encoded prion protein, PrP...
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Peptides for early diagnosis and therapy of AD

The "amyloid cascade hypothesis" assigns the amyloid-beta-peptide (Aβ) a central role in the pathogenesis of AD.
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Development of the signal in sensory rhodopsin (SR) and its transfer to the cognate transducer

Investigation of membrane proteins in membrane mimicking detergent micelles

CD4 is a type I transmembrane glycoprotein of 58 kDa. It has an extracellular domain of 370 amino acids, one transmembrane span, and a short cytoplasmic domain of 40 residues...
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Peptides for early diagnosis and therapy of Alzheimer's Disease

The "amyloid cascade hypothesis" assigns the amyloid-beta-peptide (Aβ) a central role in the pathogenesis of AD...
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SARS CoV accessory protein 7a - Structure based prediction of function

A novel coronavirus (CoV) has been shown to be the etiologic agent of the severe acute respiratory syndrome (SARS) epidemic, which affected...
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Searching for the structural basis of SH3 domain binding specificity

Protein ligand interactions in general and interactions among proteins characterize and gover the current state and the fate, respectively, of a living cell...
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Structural alterations for proton translocation in the M state of wild-type bacteriorhodopsin.

The transport of protons across membranes is an important process in cellular bioenergetics. The light-driven proton pump bacteriorhodopsin ...
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Structure of the sensory rhodopsin II/transducer complex: a molecular basis for transmembrane signalling

The human GABAA receptor associated protein GABARAP: Implications for biological function and its regulation.

Rapid signalling at synapses between neurons is mediated by small molecules, called neurotransmitters...
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X-ray Structure of Arrestin from bovine rod outer segments

last changed 07.03.2009 | | Print