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PROCOPE project “Actuation and detection of magnetic nanoparticles”

The PROCOPE project is jointly funded by the Deutscher Akadamischer Austausch Dienst (DAAD, German Academic Exchange Service) and by Campus France (Agence française pour la promotion de l enseignement supérieur, l accueil et la mobilité international).

Project title: Actuation and detection of magnetic nanoparticles

Abstract: Goal of the project is the development of magnetic actuation and detection techniques for magnetic nanoparticles on a microfluidic platform. To achieve this, a magnetic actuation unit (so-called “magnetic tweezers”) and a selective magnetic detection unit (for magnetic particle detection) shall be combined for the first time. For the sensitive detection of the magnetic particles, liquid nitrogen cooled Superconducting Quantum Interference Devices (SQUID) made from high temperature superconductors shall be put to use. In order to achieve an improvement of sensitivity, they shall be operated in a cryostat with a minimized cold-warm distance . Because of its high selectivity for magnetic nanoparticles, the new magnetic detection technique of nonlinear alternating field susceptometry and magnetic frequency mixing shall be used. This technique is based on the generation of frequency mixing signals (harmonics and intermodulation products) at the nonlinear magnetization characteristics of superparamagnetic nanoparticles upon excitation with magnetic fields of two distinct frequencies. Because the frequency mixing components are only generated from the magnetic particles due to their nonlinear magnetization, the technique is so highly selective to the particles. As a sample platform, microfluidic structures are to be used in conjunction with microwire arrays for magnetic actuation. They shall be calculated regarding optimum parameters and manufactured. With the help of these actuation structures, analyte and reagent volumes shall be mixed and separated in a controlled way. In both cases, the magnetic particles act as magnetic handles as well as magnetic markers, due to their superparamagnetic properties. For characterisation of the binding state of the magnetic particles, the three magnetic measurement techniques Magnetorelaxometry, AC susceptometry and nonlinear AC susceptometry shall be used.

Principal Investigator(s): Krause, Hans-Joachim

Partner:  Forschungszentrum Jülich, Université Pierre et Marie Curie (Paris) 

Project start: 01.01.2014

Project end: 31.12.2015

Status:   Granted