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Fabrication of gold micro-spine structures for improvement of cell/device adhesion

Article to appear in Microelectronic Engineering

Gregory Panaitov, Simon Thiery, Boris Hofmann and Andreas Offenhäusser

Institut für Bio- und Nanotechnologie (IBN) and JARA-Fundamentals of Future Information Technology, Forschungszentrum Jülich, D-52425 Jülich, Germany

Available online 30 December 2010

meldung 2011-02-02-fig1Spine array and examples of single gold spines of different shape and size

Abstract: Improvement of the interface contact between biological objects and electronic devices can significantly enhance the quality of electronic signal transfer. The surface of biosensor can be artificially modified in order to strengthen the adhesion of biological cells. We report on results of fabrication of micron and submicron golden spines by means of e-beam lithography and electroplating. The fabrication technique allows easy modification of the size and shape of golden spines by variation of processing parameters. The structures with different spine profiles and spacing have been fabricated for optimization of cell growth conditions. We present the results of growth of rat cortical neurons on the surface of spine modified samples. Well-defined cell guidance was established at the spine arrays. Furthermore, the results of transmission electron microscope and focused ion beam technique confirm the good adhesion between the spines and cell structures.