Magnetic Nanoparticle Sensing
Magnetic nanoparticles are synthesized using the thermal decomposition technique. Our research is aimed at developingmagnetic assays for sensitive detection of proteins and viruses. Magnetic markers can be applied for actuation as well as for detection.
Magnetic Nanoparticle Synthesis
Magnetic nanoparticles of different sizes and compositions are synthesized using thermal decomposition of Iron(III) acetylacetonate in a hot organic solvent. After ligand exchange through the reaction of the particles with 2,3-dimercaptosuccinic acid (DMSA), the particles can be dispersed in water. HRTEM images taken at the Central Facility for Electron Microscopy of RWTH Aachen show the crystallinity of the particles
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In order to control the synthesis and functionalization of magnetic nanoparticles (MNP) and in order to develop magnetic assays, it is essential to be able to characterise MNP’s magnetically. In our lab, we have set up experimental systems to perform Magnetorelaxometry (MRX), AC-Susceptometry (ACS) and nonlinear AC-Susceptometry (NL-ACS).
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The aim is to establish magnetic label-based immunoassays which employ the highly specific interaction between antigenes and antibodies in conjunction with magnetic nanoparticle markers for the detection and quantification of specific biomolecules.
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