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Bioimaging of Metals in Brain

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LA-ICP-MS (laser ablation inductively coupled plasma mass spectrometry) enables imaging of thin clinical tissue sections to study the distribution of essential and beneficial elements such as Zn, Cu, Fe, S, P, Se and Mn as well as of toxic and also radioactive metals (e.g., Hg, Pb, Cd, Th and U) with a spatial resolution in the µm range. By means of two-dimensional (2D) imaging of brain tissues, a defined sample area (several cm²) of a thin section of brain tissue (thickness: 20 - 50 µm) is ablated line by line with a focused laser beam.

  • Bioimaging of essential metals (e.g., Cu, Zn, Fe, Mn) and toxic metals (e.g., Pb) in human brain tissue
    • Human hippocampus
    • Human brain cortex
    • Human brain hemisphere
  • Bioimaging of metals and non-metals in rat / mouse brain tissue
    • Aging studies
    • Parkinson's diseased brain
    • Alzheimer's diseased studies
    • Study of brain infarct and haematoma
  • Metal distribution in tumor region and tumor growth
    • Metal distribution in human brain tumor: (glioblastoma multiforme - GBM)
    • Tumor growth on rat brains

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