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Giorgetti

Prof. Alejandro Giorgetti

Associate Professor

 

Professional career

2018 - Associate Professor at the University of Verona, Department of Biotechnology, Verona, Italy

2015 - Research Associate at IAS-5/INM-9 Computational Biomedicine, Forschungszentrum Jülich, Jülich, Germany

2011 - 2014 Visiting Scientist at the German Research School for Simulation Sciences GmbH (GRS), Jülich, Germany.

2007 - 2017 Assistant Professor (tenured) at University of Verona, Department of Biotechnology, Verona, Italy.

2006 - 2009 Research fellow at the Bioinformatics Program, CRS4, Pula (CA), Sardegna, Italy.

2004 - 2007 Postdoctoral research fellow at the Biocomputing Unit, Department of Biochemical Sciences, University of Rome "La Sapienza". Rome, Italy.

10.10.2004 PhD in statistical and biological physics, cum laude at the International School for Advanced Studies (SISSA/ISAS), Trieste, Italy

2000 Master degree in Medical Physics at the Universidad de Buenos Aires (UBA), Buenos Aires, Argentina

1999 - 2000 Quality Control expert of the SPECT system. Sanatorio Privado del Sur. Bahia Blanca, Argentina.

18.12.1996 Licenciado en Fisica (Degree in Physics) at the Universidad Nacional del Sur (UNS). Bahia Blanca, Argentina.

 

Structural Neuroinformatics

Apply, create and maintain web-accessible databases of experimental and computational data, together with innovative software tools, essential for understanding the structure/function of proteins expressed in the nervous system in its normal function and in neurological disorders. Structural Neuroinformatics compresses data obtained by traditional structural bioinformatics of proteins expressed in the brain, combined with computational biophysics calculations performed on wild-type proteins together with proteins modified in relation to brain functioning/malfunctioning.
a) Receptors involved in chemoperception: Bitter taste receptors and olfactory receptors.
b) Development of multiscale approaches aimed at gaining insights into the structure function of receptors of neurobiological interest: GOMoDo server for modelling and docking of GPCR receptors and the coarse-grained/molecular mechanics (MM/CG) hybrid approach; MERMAID web-server for preparing and running CGMD simulations of membrane proteins.
c) Bridging in silico molecular description of synaptic receptors with a systems biology level description of the signaling mechanisms.

 

Publications
(*: corresponding author, #: ‘equally contributing authors’).

International peer reviewed journals

 - Last five years (2015 - 2019)

1.     Damre, M, Marchetto, A., Giorgetti A*. MERMAID: dedicated web server to prepare and run coarse-grained membrane protein dynamics (2019) Nucleic Acid Res. 47, (W1), pp. W456–W461

2.     Amundarain, M.J., Viso, J.F., Zamarreño, F., Giorgetti, A.*, Costabel, M. Orthosteric and benzodiazepine cavities of the α1β2γ2 GABAA receptor: insights from experimentally validated in silico methods (2019) Journal of Biomolecular Structure and Dynamics, 37 (6), pp. 1597-1615.

3.     Alfonso-Prieto, M., Giorgetti, A.#, Carloni, P. Multiscale simulations on human Frizzled and Taste2 GPCRs (2019) Current Opinion in Structural Biology, 55, pp. 8-16.

4.     Fierro F, Giorgetti A, Carloni P, Meyerhof W, Alfonso-Prieto M. Dual binding mode of "bitter sugars" to their human bitter taste receptor target. Sci Rep. 2019 Jun 11;9(1):8437

5.     Amundarain, M.J., Ribeiro, R.P., Costabel, M.D., Giorgetti, A*. GABA A receptor family: Overview on structural characterization (2019) Future Medicinal Chemistry, 11 (3), pp. 229-246.

6.     Cao, R.; Giorgetti, A.; Bauer, A.; Neumaier, B.; Rossetti, G.; Carloni, P. Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study. (2018) Molecules 23, 2616

7.     Capaldi, S., Suku, E., Antolini, M., Di Giacobbe, M., Giorgetti, A*, Buffelli, M. Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production (2018) Scientific Reports, 8 (1), art. no. 11102

8.     Busato M, Distefano R, Bates F, Karim K, Bossi AM, López Vilariño JM, Piletsky S, Bombieri N, Giorgetti A.* MIRATE: MIps RATional dEsign Science Gateway. J Integr Bioinform. 2018 Jun 13. [Epub ahead of print]

9.     Mechaly, A.S., Tovar-Bohórquez, M., Mechaly, A.E., Suku, E., Giorgetti, A., Pérez, M., Ortí, G., Viñas, J., Somoza, G.M. Evidences of alternative splicing as a regulatory mechanism for Kissr2 in pejerrey fish.  (2018) Frontiers in Endocrinology 9, 604

10.  Zeng, J., Guareschi, R., Damre, M., Cao, R., Kless, A., Neumaier, B., Bauer, A., Giorgetti, A.*, Carloni, P., Rossetti, G. Structural prediction of the dimeric form of the mammalian translocator membrane protein TSPO: A key target for brain diagnostics (2018) International Journal of Molecular Sciences, 19 (9), art. no. 2588.

11.  Amundarain, M.J., Viso, J.F., Zamarreño, F., Giorgetti, A*, Costabel, M. Orthosteric and benzodiazepine cavities of the α1 β2 γ2 GABAA receptor: insights from experimentally validated in silico methods. (2018) Journal of Biomolecular Structure and Dynamics, pp. 1-19. Article in Press.

12.  Schneider, J., Korshunova, K., Musiani, F., Alfonso-Prieto, M., Giorgetti, A., Carloni, P. Predicting ligand binding poses for low-resolution membrane protein models: Perspectives from multiscale simulations (2018) Biochemical and Biophysical Research Communications, 498 (2), pp. 366-374.

13.  Zamarreño, F., Giorgetti, A., Amundarain, M.J., Viso, J.F., Córsico, B., Costabel, M.D. Conserved charged amino acids are key determinants for fatty acid binding proteins (FABPs)-membrane interactions. A multi-methodological computational approach (2018) Journal of Biomolecular Structure and Dynamics, 36 (4), pp. 861-877.

14.  Tarenzi T, Calandrini V, Potestio R, Giorgetti A, Carloni P. Open Boundary Simulations of Proteins and Their Hydration Shells by Hamiltonian Adaptive Resolution Scheme. J Chem Theory Comput. (2017) 13 (11), pp. 5647-5657.

15.  Fierro F, Suku E, Alfonso-Prieto M, Giorgetti A*, Cichon S, Carloni P. Agonist binding to chemosensory receptors: a systematic bioinformatics analysis (2017) Frontiers in Molecular Biosciences 4 (SEP), art. no. 63

16.  Radu BM, Osculati AMM, Suku E, Banciu A, Tsenov G, Merigo F, Di Chio M, Banciu DD, Tognoli C, Kacer P, Giorgetti A, Radu M, Bertini G, Fabene PF. All muscarinic acetylcholine receptors (M1-M5) are expressed in murine brain microvascular endothelium (2017) Scientific Reports 7(1): 5083

17.  Ponzoni, L., Rossetti G., Maggi, L., Giorgetti A., Carloni P. and Micheletti C. Unifying view of mechanical and functional hotspots across class A GPCRs. (2017) PLOS Comp. Biology Feb 3;13(2): e1005381

18.  Minnerop, M., Kurzwelly, D., Wagner, H.,  Soehn, AS.,  Reichbauer, J.,  Tao, F.,  Rattay, TW.,  Peitz,  M., Rehbach, K., Giorgetti, A.,  Pyle, A.,  Thiele, H.,  Altmüller, J.,  Timmann, D., Karaca, I.,  Lennarz, M.,  Baets, J., Hengel, H.,  Synofzik, M.,  Atasu, B.,  Feely ,S.,  Kennerson, M.,  Stendel, C.  Lindig, T.,  Gonzalez, MA.,  Stirnberg, R.,  Sturm, M.,  Roeske, S.,  Jung, J., Bauer, P., Lohmann, E.,  Herms, S.,  Heilmann-Heimbach, S., Nicholson, G., Mahanjah, M., Sharkia, R.,  Carloni, P., Brüstle, O., Klopstock, T.,  Mathews, KD.,  Shy, ME., de Jonghe, P.,  Chinnery, PF.,  Horvath, R.,  Kohlhase, J.,  Schmitt, I.,  Wolf, M.,  Greschus, S.,  Amunts, K.,  Maier, W., Schöls, L., Nürnberg, P.,  Zuchner, S.,  Klockgether, T.,  Ramirez, A. and  Schüle, R.  Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. (2017) BRAIN 140 (6): 1561-1578

19.  Suku, E., Fierro, F., Giorgetti, A.*, Alfonso-Prieto, M. and Carloni, P. Multi-scale simulations of membrane proteins: The case of bitter taste receptors. (2017) Journal of Science: Advanced Materials and Devices (in press)

20.   Sena, D. Jr, Cong, X., Giorgetti, A., Kless, A., and Carloni, P. Structural
heterogeneity of the μ-opioid receptor’s conformational ensemble in
the apo state. (2017) Scientific Reports 8: 45761

21.  Piubelli C., Castagna A., Marchi G., Rizzi M., Busti F., Badar S., Marchetti M., De Gobbi M., Roetto A., Xumerle L., Suku E., Giorgetti A., Delledonne M., Olivieri O., Girelli D. Identification of New BMP6 Pro-Peptide Mutations in Patients with Iron-Overload (2017) American Journal of Hematology 92 (6), pp. 562-568

22.  Bates F., Busato M., Piletska E., Whitcombe MJ., Karim K., Guerreiro A., Del Valle M., Giorgetti A., and Piletsky S. Computational design of molecularly imprinted polymer for direct detection of melamine in milk. (2017) Separation Science and Technology 52 (8), pp. 1441-1453

23.  Ariani, P., Regaiolo, A., Lovato, A., Giorgetti, A., Wong, D., Porceddu, A., Camiolo, S., Castellarin, S., Vandelle, A., Polverari, A. Genome-wide characterisation and expression profile of the grapevine ATL ubiquitin ligase family reveal biotic and abiotic stress-responsive and development-related members (2016). Scientific Reports; 6:38260

24.  Dindo M, Montioli R, Busato M, Giorgetti A, Cellini B, Voltattorni CB. Effects of interface mutations on the dimerization of alanine glyoxylate aminotransferase and implications in the mistargeting of the pathogenic variants F152I and I244T (2016) Biochimie, pii: S0300-9084(16)30230-9

25.  Busato, M., Giorgetti, A*. Structural modeling of G-protein coupled receptors: An overview on automatic web-servers (2016) International Journal of Biochemistry and Cell Biology 77, pp. 264-274.

26.  Vallone, R., La Verde, V., D'Onofrio, M., Giorgetti, A., Dominici, P., Astegno, A. Metal binding affinity and structural properties of calmodulin-like protein 14 from Arabidopsis thaliana (2016) Protein Science, pp. 1461-1471.

27.  Kumar, N., Astegno, A., Chen, J., Giorgetti, A., Dominici, P. Residues in the distal heme pocket of arabidopsis non-symbiotic hemoglobins: Implication for nitrite reductase activity (2016) International Journal of Molecular Sciences, 17 (5), art. no. 640

28.  Sousa, S.A., Leitão, J.H., Martins, R.C., Sanches, J.M., Suri, J.S., Giorgetti, A. Bioinformatics Applications in Life Sciences and Technologies (2016) BioMed Research International, 2016, art. no. 3603827 (Editorial)

29.  Serena, M., Giorgetti, A., Busato, M., Gasparini, F., Diani, E., Romanelli, M.G., Zipeto, D. Molecular characterization of HIV-1 Nef and ACOT8 interaction: Insights from in silico structural predictions and in vitro functional assays (2016) Scientific Reports, 6, art. no. 22319.

30.  Badar, S., Busti, F., Ferrarini, A., Xumerle, L., Bozzini, P., Capelli, P., Pozzi-Mucelli, R., Campostrini, N., De Matteis, G., Marin Vargas, S., Giorgetti, A., Delledonne, M., Olivieri, O., Girelli, D. Identification of novel mutations in hemochromatosis genes by targeted next generation sequencing in Italian patients with unexplained iron overload (2016) American Journal of Hematology, 91 (4), pp. 420-425.

31.  Rossetti, G., Dibenedetto, D., Calandrini, V., Giorgetti, A.*, Carloni, P. Structural predictions of neurobiologically relevant G-protein coupled receptors and intrinsically disordered proteins. (2015) Archives of Biochemistry and Biophysics, 582, art. no. 6948, pp. 91-100.

32.  Lovato P, Giorgetti A, Bicego M. A Multimodal Approach for Protein Remote Homology Detection. IEEE/ACM Trans Comput Biol Bioinform. 2015 Sep-Oct;12(5):1193-8

33.  Ceccon, A., Busato, M., Pérez Santero, S., D'Onofrio, M., Musiani, F., Giorgetti, A., Assfalg, M. Transient interactions of a cytosolic protein with macromolecular and vesicular cosolutes: Unspecific and specific effects (2015) ChemBioChem, 16 (18), pp. 2633-2645.

34.  Sandal, M., Behrens, M., Brockhoff, A., Musiani, F., Giorgetti, A.*, Carloni, P., Meyerhof, W. Evidence for a Transient Additional Ligand Binding Site in the TAS2R46 Bitter Taste Receptor. (2015) Journal of Chemical Theory and Computation, 11 (9), pp. 4439-4449.

35.  Pizzolo, F., Friso, S., Morandini, F., Antoniazzi, F., Zaltron, C., Udali, S., Gandini, A., Cavarzere, P., Salvagno, G., Giorgetti, A., Speziali, G., Choi, S.-W., Olivieri, O. Apparent mineralocorticoid excess by a novel mutation and epigenetic modulation by HSD11B2 promoter methylation. (2015) Journal of Clinical Endocrinology and Metabolism, 100 (9), pp. E1234-E1241.

36.  Costantini, S., Malerba, G., Contreas, G., Corradi, M., Marin Vargas, S.P., Giorgetti, A., Maffeis, C. Genetic and bioinformatics analysis of four novel GCK missense variants detected in Caucasian families with GCK MODY phenotype. (2015) Clinical Genetics, 87 (5), pp. 440-447.

37.  Astegno, A., Allegrini, A., Piccoli, S., Giorgetti, A., Dominici, P. Role of active-site residues Tyr55 and Tyr114 in catalysis and substrate specificity of Corynebacterium diphtheriae C-S lyase. (2015) Proteins: Structure, Function and Bioinformatics, 83 (1), pp. 78-90.

- Previous years (2003 - 2014)

38.  Grison A, Zucchelli S, Urzì A, Zamparo I, Lazarevic D, Pascarella G, Roncaglia P, Giorgetti A, Garcia-Esparcia P, Vlachouli C, Simone R, Persichetti F, Forrest AR, Hayashizaki Y, Carloni P, Ferrer I, Lodovichi C, Plessy C; FANTOM Consortium, Carninci P, Gustincich S. Mesencephalic dopaminergic neurons express a repertoire of olfactory receptors and respond to odorant-like molecules. BMC Genomics. 2014 Aug 27;15:729.

39.  Montioli R, Dindo M, Giorgetti A, Piccoli S, Cellini B, Voltattorni CB. A comprehensive picture of the mutations associated with aromatic amino acid decarboxylase deficiency: from molecular mechanisms to therapy implications. Hum Mol Genet. 2014 Oct 15;23(20):5429-40.

40.  Giorgetti, A*. Membrane Proteins: Insights from computational biology. (2014) Biology and Medicine, 6 (1), art. no. 1000e101.

41.  Piccoli, S., Musiani, F., Giorgetti, A*. Dynamic characterization and substrate binding of cis-2,3 dihydrobiphenyl-2,3-diol dehydrogenase—an enzyme used in bioremediation. (2014) Journal of Molecular Modeling, 20 (12), 6 p.

42.  Musiani, F., Rossetti, G., Giorgetti, A.*, Carloni, P. Chemosensorial G-proteins-coupled receptors: A perspective from computational methods. (2014) Advances in Experimental Medicine and Biology, 805, pp. 441-457.

43.  Piccoli, S., Andreolli, M., Giorgetti, A., Zordan, F., Lampis, S., Vallini, G. Identification of aldolase and ferredoxin reductase within the dbt operon of Burkholderia fungorum DBT1. (2014) Journal of Basic Microbiology, 54 (5), pp. 464-469.

44.  Giorgetti, A*. Multi-scale computational biology (2014) Biology and Medicine, 6 (1), art. no. 1000e102.

45.  Sandal, M., Paltrinieri, D., Carloni, P., Musiani, F., Giorgetti, A.* Structure/Function Relationships of Phospholipases C Beta. (2013) Current Protein and Peptide Science, 14 (8), pp. 650-657.

46.  Astegno, A., Giorgetti, A., Allegrini, A., Cellini, B., Dominici, P. Characterization of C-S lyase from C. diphtheriae: A possible target for new antimicrobial drugs. (2013) BioMed Research International, 2013, art. no. 701536.

47.  Sandal, M., Duy, T.P., Cona, M., Zung, H., Carloni, P., Musiani, F., Giorgetti, A*. GOMoDo: A GPCRs Online Modeling and Docking Webserver. (2013) PLoS ONE, 8 (9), art. no. e74092.

48.  Piccoli, S., Suku, E., Garonzi, M., Giorgetti, A*. Genome-wide membrane protein structure prediction. (2013) Current Genomics, 14 (5), pp. 324-329.

49.  Marchiori, A., Capece, L., Giorgetti, A., Gasparini, P., Behrens, M., Carloni, P., Meyerhof, W. Coarse-Grained/Molecular Mechanics of the TAS2R38 Bitter Taste Receptor: Experimentally-Validated Detailed Structural Prediction of Agonist Binding. (2013) PLoS ONE, 8 (5), art. no. e64675.

50.  Bisha, I., Laio, A., Magistrato, A., Giorgetti, A., Sgrignani, J. A candidate ion-retaining state in the inward-facing conformation of sodium/galactose symporter: Clues from atomistic simulations. (2013) Journal of Chemical Theory and Computation, 9 (2), pp. 1240-1246.

51.  Leguèbe, M., Nguyen, C., Capece, L., Hoang, Z., Giorgetti, A.*, Carloni, P. Hybrid Molecular Mechanics/Coarse-Grained Simulations for Structural Prediction of G-Protein Coupled Receptor/Ligand Complexes. (2012) PLoS ONE, 7 (10), art. no. e47332.

52.  Giorgetti, A., Ruggerone, P., Pantano, S., Carloni, P. Advanced computational methods in molecular medicine. (2012) Journal of Biomedicine and Biotechnology, 2012, art. no. 709085, .

53.  Zanzoni, S., Assfalg, M., Giorgetti, A., D'Onofrio, M., Molinari, H. Structural requirements for cooperativity in ileal bile acid-binding proteins. (2011) Journal of Biological Chemistry, 286 (45), pp. 39307-39317.

54.  Biarnés, X., Marchiori, A., Giorgetti, A.*, Lanzara, C., Gasparini, P., Carloni, P., Born, S., Brockhoff, A., Behrens, M., Meyerhof, W. Insights into the binding of phenyltiocarbamide (PTC) agonist to its target human TAS2R38 bitter receptor. (2010) PLoS ONE, 5 (8), art. no. e12394.

55.  Griguoli, M., Maul, A., Nguyen, C., Giorgetti, A., Carloni, P., Cherubini, E. Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons. (2010) Journal of Neuroscience, 30 (32), pp. 10773-10783.

56.  Saga, G., Giorgetti, A., Fufezan, C., Giacometti, G.M., Bassi, R., Morosinotto, T. Mutation analysis of violaxanthin de-epoxidase identifies substrate-binding sites and residues involved in catalysis. (2010) Journal of Biological Chemistry, 285 (31), pp. 23763-23770.

57.  Heller, D.M., Giorgetti, A*. NMR constraints analyser: A web-server for the graphical analysis of NMR experimental constraints. (2010) Nucleic Acids Research, 38 (SUPPL. 2), art. no. gkq484, pp. W628-W632.

58.  Mazzolini, M., Marchesi, A., Giorgetti, A., Torre, V. Gating in CNGA1 channels. (2010) Pflugers Archiv European Journal of Physiology, 459 (4), pp. 547-555.

59.  Maullu, C., Raimondo, D., Caboi, F., Giorgetti, A., Sergi, M., Valentini, M., Tonon, G., Tramontano, A. Site-directed enzymatic PEGylation of the human granulocyte colony-stimulating factor. (2009) FEBS Journal, 276 (22), pp. 6741-6750.

60.  Lupieri, P., Nguyen, C.H.H., Bafghi, Z.G., Giorgetti, A., Carloni, P. Computational molecular biology approaches to ligand-target interactions. (2009) HFSP Journal, 3 (4), pp. 228-239.

61.  Raimondo, D., Giorgetti, A., Bernassola, F., Melino, G., Tramontano, A. Modelling and molecular dynamics of the interaction between the E3 ubiquitin ligase Itch and the E2 UbcH7. (2008) Biochemical Pharmacology, 76 (11), pp. 1620-1627.

62.  Albiero, E., Madeo, D., Ruggeri, M., Bernardi, M., Giorgetti, A., Rodeghiero, F. Loss of the JAK2 intramolecular auto-inhibition mechanism is predicted by structural modelling of a novel exon 12 insertion mutation in a case of idiopathic erythrocytosis. (2008) British Journal of Haematology, 142 (6), pp. 986-990.

63.  Cozzetto, D., Giorgetti, A., Raimondo, D., Tramontano, A. The evaluation of protein structure prediction results. (2008) Molecular Biotechnology, 39 (1), pp. 1-8.

64.  Moutran, A., Balan, A., Ferreira, L.C., Giorgetti, A., Tramontano, A., Ferreira, R.C. Structural model and ligand interactions of the Xanthomonas axonopodis pv. citri oligopeptide-binding protein. (2007) Genetics and molecular research: GMR, 6 (4), pp. 1169-1177.

65.  Tramontano, A., Cozzetto, D., Giorgetti, A., Raimondo, D. The assessment of methods for protein structure prediction. (2007) Methods in Molecular Biology, 413, pp. 43-57.

66.  Tress, M.L., Martelli, P.L., Frankish, A., Reeves, G.A., Wesselink, J.J., Yeats, C., Ólason, P.Í., Albrecht, M., Hegyi, H., Giorgetti, A., Raimondo, D., Lagarde, J., Laskowski, R.A., López, G., Sadowski, M.I., Watson, J.D., Fariselli, P., Rossi, I., Nagy, A., Kai, W., Størling, Z., Orsini, M., Assenov, Y., Blankenburg, H., Huthmacher, C., Ramírez, F., Schlicker, A., Denoued, F., Jones, P., Kerrien, S., Orchard, S., Antonarakis, S.E., Reymond, A., Birney, E., Brunak, S., Casadio, R., Guigo, R., Harrow, J., Hermjakob, H., Jones, D.T., Lengauer, T., Orengo, C.A., Patthy, L., Thornton, J.M., Tramontano, A., Valencia, A. The implications of alternative splicing in the ENCODE protein complement. (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (13), pp. 5495-5500.

67.  Raimondo, D., Giorgetti, A., Bosi, S., Tramontano, A. Automatic procedure for using models of proteins in molecular replacement. (2007) Proteins: Structure, Function and Genetics, 66 (3), pp. 689-696.

68.  Nair, A.V., Mazzolini, M., Codega, P., Giorgetti, A., Torre, V. Locking CNGA1 channels in the open and closed state. (2006) Biophysical Journal, 90 (10), pp. 3599-3607

69.  Giorgetti, A., Raimondo, D., Miele, A.E., Tramontano, A. Evaluating the usefulness of protein structure models for molecular replacement. (2005) Bioinformatics, 21 (SUPPL. 2), pp. ii72-ii76.

70.  Giorgetti, A., Carloni, P., Mistrik, P., Torre, V. A homology model of the pore region of HCN channels. (2005) Biophysical Journal, 89 (2), pp. 932-944.

71.  Giorgetti, A., Nair, A.V., Codega, P., Torre, V., Carloni, P. Structural basis of gating of CNG channels. (2005) FEBS Letters, 579 (9), pp. 1968-1972.

72.  Giorgetti, A., Carloni, P. Molecular modeling of ion channels: Structural predictions. (2003) Current Opinion in Chemical Biology, 7 (1), pp. 150-156.

 

Book chapters

  1. Musiani F and Giorgetti A. Protein Aggregation and Molecular Crowding: Perspectives From Multiscale Simulation. In: Early Stage Protein Misfolding and AmyloidAggregation, 2017 . Vol 329, IRCMB, UK: Academic Press, 2017, pp. 49-77.
  2. Giorgetti A. and Carloni P. "Molecular Mechanics/Coarse-Grained models". 2014 pag 165 - 174. In 'Protein Modelling'; editor: Gábor Náray-Szab. Springer. ISBN: 978-3-319-09975-0.
  3. Giorgetti A., S. Piccoli, Knowledge Based Membrane Protein Structure Prediction: From X-Ray Crystallography to Bioinformatics and Back to Molecular Biology, in Current Trends in X-Ray Crystallography, edited by Annamalai Chandrasekaran, InTech Publisher (2011).
  4. Tress M., Casadio R., Giorgetti A., Hallin PF., Juncker AS., Kulberkyte E., Martelli PL., Raimondo D., Reeves GA., Thornton JM., Tramontano A., Wang K., Wesselink JJ., Valencia A., Alternative Splicing in the ENCODE Protein-Complement, Frishman D., Valencia A. Modern Genome Annotation: the Biosapiens Network, Wienn, Springer-Verlag, 2008.
  5. Tramontano A., Jones D., Rychlewski L., Casadio R., Martelli PL., Raimondo D., Giorgetti A., Protein structure prediction, Frishman D., Valencia A. Modern Genome Annotation: the Biosapiens Network, Wienn, Springer-Verlag, 2008.

 

Editorial activities

  • Member of the editorial board of the international journal: Scientific Reports (Nature group).
  • Member of the editorial board of: Journal of Integrative Bioinformatics.
  • Guest editor: special issue in"Advanced Computational Methods in Molecular Medicine". Journal of Biomedicine and Biotechnology.
  • Guest editor: special issue on "Bioinformatics Applications in Life Sciences and Technologies". BioMed Research International.
  • Reviewer:FEBS journal; Bioinformatics; Proteins; Biophysical journal; Amino Acids; EBJO; Protein Engineering, Design, and Selection (PEDS); Current Bioinformatics; Plos Computational Biology; Plos One, Nature Communications; Biochimie 
  • Expert Reviewer of the French National Research Agency "Blanc SVSE 5" call for proposals.
  • Expert Reviewer of the French National Research Agency "Generic Call 2017" call for proposals.
  • Expert reviewer (Revisore esterno) for the Consejo Nacional De Investigaciones Cientificas y Tecnicas (CONICET) Ministerio De Ciencia, Tecnologia E Innovacion Productiva della Repubblica Argentina, 2017
  • Expert reviewer (Revisore esterno) for the Consejo Nacional De Investigaciones Cientificas y Tecnicas (CONICET) Ministerio De Ciencia, Tecnologia E Innovacion Productiva della Repubblica Argentina, 2019





Addresses

Universita di Verona
Dept. Biotechnology
Strada Le Grazie 15
I-37134 Verona
Italy
IAS-5 / INM-9
Computational Biomedicine
Forschungszentrum Jülich
Wilhelm-Johnen-Straße
52428 Jülich

Contact

Phone: +39 045 8027801
email: alejandro.giorgetti@univr.it

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