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Dr. Thomas Mühleisen

Scientist

Research Group Genomic Imaging

Research Topics

Integrative approaches to the genetic analysis of the variability of structural and functional features (endophenotypes) of the human brain

My research focuses on the following topics:

  • Influence of genetic variation (single-nucleotide polymorphisms) on a neurobiological substrate (grey matter volume) for neuropsychiatric diseases (schizophrenia, bipolar disorder, depression) using GWAS
  • Identification of phonology-related genes and functional characterization of Broca's and Wernicke's regions in language and learning disorders using JuGEx
  • Gene expression regulation (expressed quantitative trait loci) in the cerebellum and its role in the risk of neuropsychiatric diseases using JuGEx

Methods and Tools

  • Genome-wide association studies (GWAS) and secondary analyses (biological pathways, polygene Scores)
  • Differential gene expression analysis (JuGEx) by combining data from the Allen Brain Atlas (RNA expression in bulk tissue) and Julich-Brain Atlas (probabilistic maps based on cytoarchitecture)
  • Isolation of nucleic acids from brain tissue and biobanking

Address

Institute of Neuroscience and Medicine (INM-1)
Forschungszentrum Jülich
52425 Jülich

Contact

Phone: +49 2461 61-5307
Fax: +49 2461 61-3483
email: t.muehleisen@fz-juelich.de