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Advertising division: IBG-1 - Biotechnology
Reference number: 2019M-004, (bio)informatics, (bio)physics, biotechnology, (bio)mathematics and similar

Master Thesis: Microbial cell-cell variability investigation with microfluidic single-cell analysis

The IBG-1 develops cutting edge microfluidic lap-on-a-chip technology to investigate cellular growth and development on the very single-cell level. The Modeling and Simulation Group uses time-lapse videos of developing populations for data-driven modelling of biological processes.

Project description:
Single-cell time-lapse microscopy has revealed heterogeneity of isogenic cells in their response to environmental changes. However, the reasons for the variability are diverse and the mechanisms that trigger the variability vastly unknown. Unravelling aspects of this question with state-of-the-art microfluidic tools in combination with image analysis and modelling has a tremendous value for basic as well as industrial research.
You will investigate physiological processes by means of growth, cell cycle, morphology and fluorescent signals with the microbial platform organisms like Escherichia coli or Corynebacterium glutamicum. You will use state-of-the-art image analysis tools and develop statistical or dynamic models to describe the data.
Specific projects are available with more modelling, computational or image analysis related focus. Ideally, the project is combined with a practical semester. Ideally the project is combined with a practical semester to acquire hands-on experiences with all steps involved in performing single-cell experiments.

Your Qualifications:
Excellent and highly motivated student of (bio)informatics, (bio)physics, biotechnology, biomathematics, control engineering or a related field with good communication skills and strong interest in interdisciplinary research as well as very good programming skills (e.g., Java, Scala, C++, Python, MATLAB).

About us:
The Modeling and Simulation Group is part of the IBG-1: Biotechnology, located at Research Center Jülich (Forschungszentrum Jülich GmbH). The project is a prime example for research at the interface of biology, engineering sciences and computational analysis. We offer an open, multidisciplinary and stimulating research environment within young and dynamic groups.

Dr. Katharina Nöh |
Christian Sachs, MSc. |

Modeling and Simulation Group
IBG-1: Biotechnology
Forschungszentrum Jülich
52425 Jülich

Announcement as pdf file:  Master thesis: Microbial cell-cell variability investigation with microfluidic single-cell analysis (2019M-004) (PDF, 239 kB)