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Advertising division: IBG-1 - Biotechnology
Reference number: 2019M-093, Biochemistry, applied chemistry, biotechnology

Bachelor or Master thesis in the HOTZYMES project

The focus of the `Synthetic enzyme cascades´ (aka Biokat) group is to develop multienzymatic cascades towards high-value products (eg. pharmaceuticals), which cannot be easily obtained from nature or from chemical synthesis, usually starting from bio-based and cheap substrates.

The HOTZYMES project:
This cutting-edge project envisions the on-demand activation and regulation of enzymatic activity in one-pot multi-enzymatic cascade system by applying an alternating magnetic field (AMF) to it. The main challenges for this project are: (i) coordinating the optimal reaction conditions for one-pot multi-enzymatic system, (ii) matching the optimal temperature for each enzyme, and (iii) avoid cross-reactivity of enzymes and the formation of by-products. The overall aim of HOTZYMES is to tackle these challenges simultaneously by gaining selective spatial-temporal control over each enzyme activity by means of local heating due to molecular movement induced by a magnetic field. This is a FET-OPEN project funded by the Horizon 2020 EU program and is part of an interdisciplinary consortium involving seven partners across Europe.

More information can be found in our website:

Your qualifications:
We are looking for a highly motivated student of biochemistry, applied chemistry, biotechnology, or a related field with (very) good grades and strong interest in interdisciplinary research. Prior hands-on experience with microbiology, biocatalysts and instrumental analytics (photometric assays, HPLC, and NMR) would be very advantageous. Good English skills are also expected.


Please send your application (CV, Abitur certificate, current transcript of records) via e-mail to: e
Dr. Eduardo Melo
Forschungszentrum Jülich
Institute of Bio- and Geosciences
IBG-1: Biotechnology

Announcement as pdf file:  Bachelor or Master thesis in the HOTZYMES project (PDF, 178 kB)