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Advertising division: ER-C-3 - Structural Biology
Reference number: 2019-411


The Ernst Ruska-Centre (ER-C) at the Forschungszentrum Jülich houses some of the world`s most advanced electron microscopes and tools for nanocharacterisation. The scientific research covers current issues in condensed matter physics and from now on cryo-EM on biomacromolecules and in the future development of electron microscopy. The ER-C has a total of 13 electron microscopes including the PICO FEI Titan with a point resolution of 0.5 Å. The facility has been extended with state-of-the-art cryo-microscopes FEI Talos Arctica including Bioquantum K3 and FEI Talos 120. The Structural Biology subinstitute ER-C-3 investigates the structural and molecular mechanism of autophagy and pushes the development of cryo-EM related methodology. The Jülich campus hosts a vibrant electron microscopy, biophysics and structural biology community.

We are seeking to recruit a

Structural biology scientist - Protein purification

Your Job:

  • Design, cloning and expression for purification of recombinant proteins and macromolecular complexes
  • Developing of protein production methods in multiple expressions systems, such as E.coli, insect cell culture and human cell culture
  • Functional and biophysical characterization of purified Proteins
  • Screening, data acquisition and structure determination of purified cryo-EM samples

Your Profile:

  • You have ample experience in structural biology related protein purification methods and apply them to challenging molecular systems
  • You are a team player with excellent interpersonal and communication skills as well as supervisory skills
  • You are experienced with multiple protein expression systems
  • As a rigorous scientist you are passionate about innovation, especially in establishing new purification procedures for macromolecular complexes
  • You are highly motivated participating in generating highly pure samples for cryo-EM structural investigation of autophagy complexes at the ER-C3 for structural biology

Our Offer:

  • A dynamically growing research environment on an interdisciplinary campus
  • 2 year appointment, continuation after 2 years subject to an intermediate evaluation
  • Flexible working hours and various opportunities to reconcile work and private life
  • Full-time position with the option of slightly reduced working hours
  • above-standard salary and social benefits in conformity with the provisions of the Collective Agreement for the Civil Service (TVöD). Depending on the applicant’s qualifications and the precise nature of the tasks, salary grade EG 13 -14 TVöD-Bund
  • 30 days leave
  • A comprehensive career development training programme

More detailed information on the scientific group led by Prof. Carsten Sachse can be found on

Forschungszentrum Jülich aims to employ more women in this area and therefore particularly welcomes applications from women.

We also welcome applications from disabled persons.