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Advertising division: IBI-1 - Molecular and Cellular Physiology
Reference number: 2020D-017


The laboratory of Christoph Fahlke in the Institute of Complex Systems - Cellular Biophysics is looking for a PhD student with a thesis project about mechanisms that regulate acidification of synaptic vesicles. We are an interdisciplinary group focusing on the molecular and cellular function of membrane transport proteins (PNAS (2013) 110, 12486-12491, Cell (2015) 160, 542-553, Glia (2017) 65, 388-400, Nat Commun (2017) 8, 2279, EMBO J (2019) e101468) and on their dysfunction in genetic and acquired human diseases (Am J Hum Genet (2009) 85, 273-280; Brain (2012) 135, 3416-3425, Sci Rep (2017) 7, 13913, Nat Genet (2018), 50, 349-354).

We are offering a

PhD Position - Acidification of synaptic vesicles

Your Job:

Synaptic vesicles harness pH gradients to accumulate neurotransmitters, and synaptic vesicle acidification is thus key to proper synaptic function. The PhD project focuses on the mechanisms underlying acidification of synaptic vesicles, with special focus on CLC-type chloride/proton exchangers. Available methods range from molecular biology, patch clamp electrophysiology, neuronal cell culture, optogenetics to fluorescence spectroscopy.

Your Profile:

  • Master degree in the field of Biology/Physics/Chemistry or related
  • High motivation and interest and/or experience in biophysics and biochemistry
  • Social competence and good communication skills for collaborative work in and with interdisciplinary teams
  • Ability to communicate in English

Our Offer:

  • Being part of a DFG funded research group FOR 2795 Synapses under stress: Early events induced by metabolic failure at glutamatergic synapses
  • Access to multiple techniques ranging from computational biology on individual proteins to the analysis of organ functions in animal models
  • Opportunity to get expertise in state-of art techniques and strategies in the field of molecular biology, patch clamp electrophysiology, neuronal cell culture, optogenetics and fluorescence spectroscopy
  • Possible membership in the International Helmholtz Research School of Biophysics and Soft Matter that provides a complementary research training at the interfaces of biology, chemistry, and physics, as well as transferable skills courses
  • A contract for the duration of 3 years
  • We will provide continuous scientific mentoring and discussions by the scientific advisor
  • The doctoral degree will be conferred by the Heinrich Heine University, Düsseldorf
  • Outstanding scientific and technical infrastructure – ideal conditions for successfully completing a doctoral degree
  • Pay in line with 50 % of pay group 13 of the Collective Agreement for the Public Service (TVöD-Bund).
  • Information on employment as a PhD student at Forschungszentrum Jülich can be found here

Forschungszentrum Jülich promotes equal opportunities and diversity in its employment relations.

We also welcome applications from disabled persons.