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IAS-Seminar "A Hidden Trigger of Alzheimer’s Disease in Diabetes"

18.03.2016 10:00 Uhr
18.03.2016 11:00 Uhr
Jülich Supercomputing Centre, Rotunde, Geb. 16.4, R. 301
Florin Despa, Ph.D., Associate Professor, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, USA
Amylin is a hormone synthesized and co-secreted with insulin by pancreatic islets that crosses the blood brain barrier and regulates satiety. Amylin from humans (but not rodents) has an increased propensity to aggregate into pancreatic islet amyloid deposits that contribute to the development of type-2 diabetes by inducing oxidative stress and inflammation. In my talk, I will present experimental results from my lab showing that elevated circulating levels of aggregated amylin negatively affect the neurons causing peroxidative membrane injury and aberrant inflammatory responses independent of other confounding factors of diabetes. In addition, amylin interacts with β amyloid (Aβ) forming mixed amylin-Aβ oligomers and plaques. Present results demonstrate a novel contributing mechanism to neurodegeneration and suggest a direct, potentially treatable link of type-2 diabetes with Alzheimer’s disease.
Freitag, 18. März 2016, 10.00 Uhr
Jülich Supercomputing Centre, Rotunde, Geb. 16.4, R. 301
Ankündigung als pdf-Datei:
 A Hidden Trigger of Alzheimer’s Disease in Diabetes (PDF, 36 kB)

Alle Interessierten sind herzlich eingeladen.
Ansprechpartner: Dr. Jan Meinke,