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Seminar by Prof. Igor Goychuk

University of Postdam (Germany)

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18 Jun 2015 12:00
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18 Jun 2015 13:00
venue
Lecture room 2009, Jülich GRS building (16.15)

Molecular motors are indispensable for deliviring various cargos such as vesicles in eukaryotic cells, e.g. along axons of neurons. Recent discovery of subdiffision of sub-micron particles in living cells poses the question on how can their transport be realized by molecular motors. Can it be normal, or is also anomalously slow, and which is its thermodynamic and transport efficiency? Recently we showed [1] that such transport can be both anomalous and normal depending, in particular, on the motor strength (related to the binding potential height), cargo size, and motor operating frequency. Morever, its thermodynamic efficiency can be very high, over 50%, even in novel anomalous transport regime characterized by anomalous motor enzyme turnovers [2]. I will discuss these results obtained within a generalization of well-known Brownian ratchet models of molecular motors towards non-Markovian dynamics with long-lasting memory based on nonlinear Generalized Langevin Equation, its multi-dimensional Markovian embedding, fluctuation-dissipation theorem, and other dynamical foundations of non-equilibrium statistical mechanics, quite in the spirit of molecular dynamics [3].
[1] I. Goychuk, V. Kharchenko, R Metzler, PLoS ONE 9, e91700 (2014); Phys. Chem. Chem. Phys. 16 , 16524 (2014).
[2] I. Goychuk, Physical Biology 12, 016013 (2015).
[3] I. Goychuk, Adv. Chem. Phys. 150, 187 (2012); Phys. Rev. 80, 046125 (2009).


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