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Seminar by Dr. Anna Letizia Allegra Mascaro

European Laboratory for Non-Linear Spectroscopy (LENS), University of Florence and National Institute of Optics (INO-CNR), Sesto Fiorentino (Italy)

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27 Oct 2015 14:00
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27 Oct 2015 15:00
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Lecture room 2009, Jülich GRS building (16.15)

Structural and Functional Imaging of Cortical Plasticity

Information processing inside the central nervous system takes place on multiple scales in both space and time. To obtain an integrated view, complementary approaches combining different imaging techniques should be combined. Two-photon fluorescence microscopy, combined with multi-photon laser nanosurgery, allow following the dynamics of damaged neurons in the cerebral cortex of living mice. We dissected the ultrastructural features of the same neuron previously imaged in vivo by means of correlative light and electron microscopy. The behavior of single cells depends on the network they are integrated, which needs to be investigated with large area optical techniques. We show how wide-field functional in vivo imaging of cortical activity with can provide useful insights into cortical remapping induced by learning or triggered by injury.


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