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Seminar by Prof. Andreas Beyer

Sybacol, Cologne (Germany)

19 Jul 2017 11:00
19 Jul 2017 12:00
Lecture room 2009, Jülich GRS building (16.15)

Understanding complex traits with molecular networks

The modulation of complex traits by genetic or environmental perturbations can only be understood by investigating the underlying molecular networks. As a first example of our contribution to this field I will present methods for identifying the networks mediating effects of natural genetic variation on molecular phenotypes such as RNA and protein levels. We have developed quantitative trait locus (QTL) mapping methods accounting for multi-locus effects including epistatic interactions. Those methods were applied to better understanding molecular changes in diverse yeast species.
As a second example I am going to show an analysis of lifespan-associated molecular networks. Multiple genetic perturbations in the nematode C. elegans extend its lifespan. However, it remains unclear to what extent these perturbations impact on common molecular processes. In order to address this question we have employed network integration methods, which allowed us to highlight molecular processes relevant for animal lifespan.