Navigation und Service

BioSoft Colloquium:

Feeling the force: molecular mechano-sensors in biological systems

Frauke Gräter

Professor of Molecular Biomechanics,
Interdisciplinary Center for Scientific Computing (IWR) at Heidelberg University and Heidelberg Institute for Theoretical Studies

Anfang
01.04.2021 11:00 Uhr
Veranstaltungsort
Remote access

Join us at: www.fz-juelich.de/ibi/TPLMSem

Abstract:

Biological systems sense and respond to mechanical forces. The hallmark of a mechano-sensing molecule is a functional switch when subjected to a mechanical force. I will present results on how we have identified, using Molecular Dynamics simulations in conjunction with single molecule force spectroscopy, protein molecules as new candidates for such mechanical switches.

Theoretical Physics Copyright: Prof. Frauke Gräter, Interdisciplinary Center for Scientific Computing (IWR) at Heidelberg University and Heidelberg Institute for Theoretical Studies

We more recently also discovered a very different way of ‘feeling the force’ which we propose to be at play in collagen, the most abundant protein of our body: Protein covalent bonds rupture under high forces, resulting in radicals and oxidative stress molecules. I will present simulations and electron-paramagnetic resonance spectroscopy experiments that show how collagen has been designed by evolution not only to carry but also to sense high mechanical loads through mechanically generated radicals.


Kontakt

Dr. Dmitry Fedosov
Telefon: +49 2461 61-2972
Fax: +49 2461 61-3180
E-Mail: d.fedosov@fz-juelich.de