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Labs! Visit on Liquid-State NMR Methods for Protein Structure Elucidation

25 Mar 2020 10:15
25 Mar 2020 11:00
building 16.13, room 2001

Melanie Schwarten
(Structural Biochemistry)

Extraordinary advances occurred during the last few years in structural biology by nuclear magnetic resonance (NMR) spectroscopy. The precision and accuracy of solution structures by NMR improved dramatically and the upper range of molecular weights accessible to NMR structure determination is still increasing.Once reasonable solution conditions are found, NMR structure determination is straight forward. Using nuclear spins in biomolecular structural studies has required exceptional efforts integrating chemical physics, instrumentation development, new algorithms, and labelling strategies. NMR can provide a realistic, dynamic and/or time averaged view of a macromolecule ligand interface or, even, the transient intramolecular interfaces seen during protein folding not available by other methods. This is an advantage in probing the role of local entropic contributions to binding using relaxation methods, and in the dissection of localized weak contributions as in the 'SAR (structure activity relationships) by NMR' approach.

Online registration is mandatory and all places are subject to availability; you will receive an email confirmation once your place on the seminar is reserved.

This Labs! event is offered in collaboration with the IFF Spring School.